Treg cells show promise as immunotherapy for Crohn's disease

NEW YORK (Reuters Health) - 13/02/2019

Crohn's disease (CD) symptoms may be reduced if an agonist of the retinoic acid receptor alpha (RARA) can be used to traffic T-regulatory (Treg) cells to inflamed intestinal tissues, researchers suggest.

Heavier red meat consumption tied to higher NAFLD risk

(Reuters Health) - 13/02/2019

People who eat a lot of animal protein may be more likely to have excessive fat in their livers and a higher risk of non-alcoholic fatty liver disease (NAFLD) than individuals whose main source of protein is vegetables, a Dutch study suggests.

GLP-1 enhances insulin secretion after bariatric surgery

NEW YORK (Reuters Health) - 12/02/2019

Glucagon-like peptide 1 (GLP-1) plays a major role in driving enhanced insulin secretion following bariatric surgery, researchers from the U.K. report.

Laparoscopic gastrectomy outcome comparable to open surgery

NEW YORK (Reuters Health) - 13/02/2019

Patients with stage I gastric cancer who undergo laparoscopic distal gastrectomy have long-term-survival rates similar to those who have open distal gastrectomy, according to a clinical trial from South Korea.

Novel radiation therapy promising for metastatic castration-resistant prostate cancer

NEW YORK (Reuters Health) - 14/02/2019

A novel, targeted radiation therapy called Lutetium-177 PSMA-617 (LuPSMA) has shown promising clinical activity in men with prostate-specific membrane antigen (PSMA)-positive metastatic, castration-resistant prostate cancer (mCRPC) that progressed despite multiple standard therapies.

Stereotactic body radiotherapy shows long-term safety in prostate cancer

NEW YORK (Reuters Health) - 14/02/2019

Stereotactic body radiotherapy (SBRT) appears to provide good long-term results and very few toxic effects in certain prostate cancers, according to data from thousands of patients.

Expanding genetic testing for prostate cancer could improve patient management

NEW YORK (Reuters Health) - 15/02/2019

Expanding genetic testing beyond current guidelines could better stratify prostate cancer patients for the presence of pathogenic variants and improve their medical management, researchers say.

Neoadjuvant anti-PD-1 immunotherapy may improve glioblastoma outcomes

NEW YORK (Reuters Health) - 15/02/2019

Neoadjuvant immunotherapy with anti-PD-1 agents may improve outcomes in patients with resectable or recurrent glioblastoma, researchers report.

Hyperthermic intraperitoneal chemo relatively safe for treating metastases

NEW YORK (Reuters Health) - 07/02/2019

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) appears to be at least as safe as other high-risk surgical oncology procedures, according to a retrospective study.

Histological subtype best outcome predictor in orbital lymphoma

NEW YORK (Reuters Health) - 08/02/2019

How well orbital lymphoma (OL) patients do depends mainly on which of four subtypes they have, a new case series suggests.

Aspirin, anticoagulants up rate of false positives with FIT for colorectal cancer

NEW YORK (Reuters Health) - 07/02/2019

Regular use of aspirin or anticoagulants reduces the positive predictive value (PPV) of fecal immunochemical testing (FIT) for detecting colorectal cancer and advanced adenomas, researchers from Norway report.

Recurrence risk constant after ablation in Barrett's esophagus

NEW YORK (Reuters Health) - 05/02/2019

Diligent surveillance remains important after remission of intestinal metaplasia (CRIM) following radiofrequency ablation (RFA) in Barrett's esophagus, researchers say.

Collagen signature helps predict lymph-node metastasis in gastric cancer

NEW YORK (Reuters Health) - 07/02/2019

In patients with early gastric cancer the collagen signature in the tumor microenvironment is an independent indicator of lymph-node metastasis, according to Chinese researchers.

Surgery may curb risk of recurrent adhesive small-bowel obstruction

NEW YORK (Reuters Health) - 08/02/2019

Surgical intervention reduces the risk that adhesive small-bowel obstruction (aSBO) will recur, whether it's done at the index episode or during recurrent episodes, researchers say.

Focal cryotherapy shows encouraging prostate cancer control

NEW YORK (Reuters Health) - 31/01/2019

Focal cryotherapy for nonmetastatic clinically significant prostate cancer shows largely good outcomes at up to three years, according to UK researchers.

Hypothermic intraperitoneal chemo relatively safe for treating metastases

NEW YORK (Reuters Health) - 31/01/2019

Cytoreductive surgery with hypothermic intraperitoneal chemotherapy (CRS/HIPEC) appears to be at least as safe as other high-risk surgical oncology procedures, according to a retrospective study.

'Dense' breast rates steady with changing guidelines and technology

NEW YORK (Reuters Health) - 30/01/2019

The percentage of digital mammography screens assessed as dense has remained steady with changes in Breast Imaging Reporting and Data System (BI-RADS) guidelines and implementation of digital breast tomosynthesis, according to findings from the Breast Cancer Surveillance Consortium (BCSC).

Improved head and neck cancer survival with NSAIDs

NEW YORK (Reuters Health) - 29/01/2019

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with improved survival in patients with PIK3CA-altered head and neck cancer, researchers report.

Azathioprine ups pancreatitis risk in pediatric IBD

NEW YORK (Reuters Health) - 31/01/2019

Azathioprine is associated with a six-fold increased risk of acute pancreatitis in children with inflammatory bowel disease (IBD), new research shows.

Glycemic control tied to better outcome of anti-VEGF therapy for diabetic macular edema

NEW YORK (Reuters Health) - 01/02/2019

Strong glycemic control may optimize vision outcomes in patients with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (anti-VEGF) therapy, researchers say.

Multiple infliximab doses better for acute severe ulcerative colitis

NEW YORK (Reuters Health) - 01/02/2019

As salvage therapy for acute severe ulcerative colitis refractory to corticosteroids, multiple infliximab doses are superior to a single dose for improving colectomy-free survival, according to a new systematic review and meta-analysis.

Adding vedolizumab to steroids may boost response, remission in Crohn's disease

NEW YORK (Reuters Health) - 30/01/2019

In patients with moderate to severe Crohn's disease who've been taking stable doses of steroids, adding vedolizumab may help induce a clinical response or remission, researchers say.

NAFLD in adolescent boys improves with low sugar diet

NEW YORK (Reuters Health) - 22/01/2019

Adolescent boys on a "low free sugar" diet show significant improvements in nonalcoholic fatty liver disease (NAFLD), according to results from an 8-week randomized clinical trial.

Soluble fiber may improve diabetes control

(Reuters Health) - 24/01/2019

People with diabetes who take soluble fiber supplements have slightly lower blood sugar than their peers who don't add this type of fiber to their diets, a research review finds.

Postpartum substance abuse, mood disorders more common with IBD

NEW YORK (Reuters Health) - 25/01/2019

Inflammatory bowel disease (IBD), and Crohn's disease in particular, is associated with an increased risk of postpartum mood disorders and substance abuse, new findings in the journal Gut show.

Younger, more insulin-sensitive T2DM patients benefit most from intensive insulin

NEW YORK (Reuters Health) - 23/01/2019

Patients with newly diagnosed type 2 diabetes can experience long-term glycemic remission with intensive insulin treatment - but this effect is more likely in younger patients and those with lower post-treatment glucose levels, according to new findings in the Journal of Clinical Endocrinology and Metabolism.

It's never too late to quit smoking before lung surgery

(Reuters Health) - 16/01/2019

Smokers preparing for lung cancer surgery should quit smoking before the operation, and the sooner the better, a new study shows.

Lung cancer screening complications may be higher than expected

(Reuters Health) - 14/01/2019

Invasive follow-up tests to examine abnormalities found with lung cancer screening may lead to more complications and extra healthcare costs than previously thought, a U.S. study suggests.

Task force adds aromatase inhibitors to advice on breast cancer chemoprevention in high-risk women

NEW YORK (Reuters Health) - 15/01/2019

In addition to tamoxifen and raloxifene, aromatase inhibitors (AIs) may now be considered for chemoprevention of breast cancer in women at high risk, the U.S. Preventive Services Task Force (USPSTF) said today in draft recommendations on the topic.

Life expectancy predicts benefit of immune-checkpoint inhibitors

NEW YORK (Reuters Health) - 15/01/2019

Late-life expectancy (LLE) is a better measure of survival benefit with immune-checkpoint inhibitors than is the American Society of Clinical Oncology Value Framework (ASCO-VF), according to a new report.

Long-lasting menopause symptoms may be tied to slightly higher breast cancer risk

(Reuters Health) - 17/01/2019

Women who experience symptoms of menopause for many years may be slightly more likely to develop breast cancer than women who never had these symptoms, a U.S. study suggests.

Tumor markers limit imaging need in germ-cell tumor surveillance

NEW YORK (Reuters Health) - 16/01/2019

Tumor markers are a sensitive, radiation-sparing means of surveillance in children and adolescents with malignant germ-cell tumors, according to a retrospective review.

Fecal-microbiota transplant beats antibiotics for recurrent C diff

NEW YORK (Reuters Health) - 16/01/2019

Fecal-microbiota transplantation (FMT) is superior to 10 days of fidaxomicin or vancomycin for resolving recurrent Clostridium difficile infection (CDI), according to results from a randomized open-label clinical trial.

Fecal-microbiota transplant boosts ulcerative colitis remission

NEW YORK (Reuters Health) - 16/01/2019

Anaerobically prepared fecal-microbiota transplantation (FMT) improved remission rates in adults with mild to moderate ulcerative colitis (UC) in a randomized trial.

Hyperglycemia tied to higher fracture risk in elderly Japanese men

NEW YORK (Reuters Health) - 17/01/2019

Community-dwelling elderly men with hyperglycemia are at elevated risk of osteoporotic fracture, according to Japanese researchers.

Routine diversion after sphincter-sparing rectal surgery tied to poorer outcomes

NEW YORK (Reuters Health) - 22/01/2019

Routine diversion after sphincter-sparing rectal cancer resection does not reduce anastomotic leaks and is associated with more reinterventions, readmissions, and higher costs, according to a database study.

Complications fewer, survival unaffected by less-invasive esophageal cancer surgery

(Reuters Health) - 09/01/2019

In patients with esophageal cancer, laparoscopic abdominal surgery combined with an open thoracotomy - i.e., hybrid minimally invasive esophagectomy - produces 77% fewer major complications than open esophagectomy without lowering survival, according to a study of more than 200 French patients reported January 9 online in The New England Journal of Medicine.

Advanced endoscopic techniques improve IBD assessment

NEW YORK (Reuters Health) - 08/01/2019

Advanced endoscopic techniques allow for better assessment of mucosal healing and dysplasia in patients with inflammatory bowel disease (IBD), according to a new review.

Need for bariatric revision varies by primary operation

NEW YORK (Reuters Health) - 02/01/2019

Bariatric reoperations are more common after banding and vertical banded gastroplasty (VBG) than after gastric bypass (GBP), according to long-term follow-up of participants in the Swedish Obese Subjects (SOS) study.

Serology an increasingly important indicator of celiac disease

NEW YORK (Reuters Health) - 09/01/2019

Serology has gained importance in the diagnosis of celiac disease (CD), due to improvements in assay performance over the last decade, according to updated advice for clinical practice.

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  • Radboud university medical center
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