News

Cardiology

"PAUSE" protocol safe for AF patients on DOAC therapy who need surgery

NEW YORK (Reuters Health) - 7/8/2019

Researchers have developed and validated a simple, standardized way to manage patients treated with a direct oral anticoagulant (DOAC) who need an elective surgery or procedure.

Catheter ablation improves outcomes in atrial fibrillation with heart failure

NEW YORK (Reuters Health) - 1/8/2019

Catheter ablation improves survival, quality of life and other outcomes in patients with atrial fibrillation (AF) complicated with heart failure (HF), according to a pooled analysis of randomized trials.

Former US pro football players may face increased risk of Afib

(Reuters Health) - 25/7/2019

Former players from the National Football League were nearly six times as likely to develop atrial fibrillation as men of the same age in the general population, in a study published July 24 in the Journal of the American Heart Association.

NOACs best for Afib in early kidney disease, but jury out in advanced CKD

NEW YORK (Reuters Health) - 15/7/2019

For patients with early-stage chronic kidney disease (CKD) who have atrial fibrillation, non-vitamin K oral anticoagulants (NOACs) have a better benefit-risk profile than vitamin K antagonists (VKAs), according to a large meta-analytic review of published studies.

Heparin bridging could worsen outcomes after stroke

NEW YORK (Reuters Health) - 9/7/2019

Bridging with low-molecular-weight heparin (LMWH) is associated with worse outcomes after stroke in patients with nonvalvular atrial fibrillation (AF), according to results from the RAF and RAF-NOACs studies.

New method of interpreting cardiac telemetry accurately spots AF in stroke patients

NEW YORK (Reuters Health) - 4/7/2019

Electrocardiomatrix, a new method of evaluating electrocardiography (ECG) signals, accurately identifies atrial fibrillation (AF) in patients admitted for ischemic stroke or transient ischemic attack (TIA), according to an observational study in a stroke unit.

DOACs better choice for Asian patients with AF and liver disease

NEW YORK (Reuters Health) - 4/7/2019

Direct oral anticoagulants (DOACs) are safer and more effective than warfarin in Asian patients with atrial fibrillation (AF) and liver disease, researchers from South Korea report.

Avoid VKA plus DAPT in AF patients undergoing PCI: meta-analysis

NEW YORK (Reuters Health) - 28/6/2019

A regimen of vitamin K antagonists (VKAs) plus dual antiplatelet therapy (DAPT) is best avoided in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI), according to a network meta-analysis of randomized controlled trials.

Atrial fibrillation tied to increased risk of dementia

NEW YORK (Reuters Health) - 27/6/2019

Atrial fibrillation (AF) is associated with an increased risk of dementia, even in individuals who have not had a stroke, a Korean database study reveals.

Beta-blockers may attenuate triggering of atrial fibrillation by anger, stress

NEW YORK (Reuters Health) - 25/6/2019

Beta-blockers appear to reduce the triggering of atrial fibrillation (AF) by anger or stress, according to results from a prospective study.

Direct oral anticoagulants, warfarin appear equally safe in morbidly obese patients

NEW YORK (Reuters Health) - 13/6/2019

Direct oral anticoagulants and warfarin appear to be similarly safe in morbidly obese patients with atrial fibrillation (AF) and venous thromboembolism (VTE), according to new findings.

Long-standing AF tied to outcomes of left-atrial-appendage occlusion

NEW YORK (Reuters Health) - 6/6/2019

Long-standing persistent atrial fibrillation (LSPAF) is associated with more residual leak following percutaneous left atrial appendage (LAA) occlusion with the Watchman device, according to one of two new studies of LAA closure.

New-onset atrial fibrillation common after aortic-valve replacement

NEW YORK (Reuters Health) - 4/6/2019

About half of inpatients who undergo transcatheter aortic-valve implantation (TAVI) or surgical aortic-valve replacement (AVR) develop new-onset atrial fibrillation (AF), according to data from the National Inpatient Sample (NIS).

Worse outcomes seen in AF patients with ischemic cardiomyopathy

NEW YORK (Reuters Health) - 23/5/2019

Patients with atrial fibrillation (AF) and ischemic cardiomyopathy have higher one-year mortality rates than similar patients with nonischemic cardiomyopathy, according to results from the GARFIELD-AF registry.

Gastroenterology

High cost of robot-assisted cholecystectomy should discourage use

NEW YORK (Reuters Health) - 9/10/2019

Robot-assisted cholecystectomy appears to be safe, but has no added benefit and costs much more than traditional laparoscopic cholecystectomy, according to a new database study.

Perioperative dietary therapy beneficial in IBD

NEW YORK (Reuters Health) - 9/10/2019

People with inflammatory bowel disease (IBD) who undergo surgery fare better if they receive perioperative dietary therapy, according to a new research review.

IBD patients have high exposure to ionizing radiation

NEW YORK (Reuters Health) - 7/10/2019

Patients in Ontario with inflammatory bowel disease (IBD), and particularly those with Crohn's disease (CD), are at risk for high exposure to ionizing radiation from abdominal computed tomography (CT) scanning, an observational study reveals.

Celiac families may not need two toasters

(Reuters Health) - 4/10/2019

Often when someone in the family has celiac disease, two sets of kitchenware are used to avoid inadvertent exposures to gluten. But a new study suggests that may not be necessary.

Laparoscopic gastrectomy may be preferable after gastric-cancer chemo

NEW YORK (Reuters Health) - 4/10/2019

In patients with locally advanced gastric cancer, laparoscopy-assisted distal gastrectomy (LADG) after neoadjuvant chemotherapy appears to offer more short-term benefits than does open gastrectomy, according to Chinese researchers.

Immune overdrive puts some colorectal cancer patients at risk for poor outcomes

NEW YORK (Reuters Health) - 4/10/2019

Immune cell infiltration of tumors is usually associated with favorable outcomes, but sometimes in colorectal cancer (CRC) the opposite is true, researchers say. They caution that Immunoscore, developed to predict CRC recurrence, may incorrectly classify high-risk patients as low risk.

Early colonoscopy does not improve outcomes in lower-GI bleeding

NEW YORK (Reuters Health) - 3/10/2019

Routine early colonoscopy in patients with acute lower-gastrointestinal bleeding (ALGIB) appears to be of little use compared with elective colonoscopy, according to new findings.

Psoriasis shows bidirectional association with IBD

NEW YORK (Reuters Health) - 27/9/2019

People with psoriasis have an increased risk of inflammatory bowel disease (IBD), and people with IBD have an increased risk of psoriasis, according to a systematic review and meta-analysis.

Liver resection in people with colorectal-cancer metastases tied to better survival

NEW YORK (Reuters Health) - 27/9/2019

Liver resection is associated with a significant survival benefit in patients with colorectal-cancer liver metastases (CRC-LM), according to an analysis of linked databases.

Robotic gastrectomy has 'significant' learning curve

NEW YORK (Reuters Health) - 25/9/2019

Robotic gastrectomy is a complex procedure, and its significant learning curve can "substantially" affect surgical outcomes, a prospective study from Korea reveals.

Mental health services use rises after bariatric surgery

(Reuters Health) - 25/9/2019

After weight-loss surgery, patients may be more likely to need mental health services, including psychiatric hospitalizations, a new study suggests.

Ustekinumab promising, vedolizumab tops adalimumab against ulcerative colitis

NEW YORK (Reuters Health) - 25/9/2019

In a head-to-head comparison, vedolizumab scored better than widely used adalimumab in treating moderately to severely active ulcerative colitis (UC) in two out of three measures, according to a report online September 25 in The New England Journal of Medicine.

Long-term data confirm benefit of H. pylori treatment in gastric cancer

NEW YORK (Reuters Health) - 24/9/2019

Antibiotic treatment of Helicobacter pylori reduces the incidence of gastric cancer and possibly related deaths, and supplementation with vitamins or garlic may also hold promise, according to long-term follow-up of the Shandong Intervention Trial.

High-intensity surveillance beneficial, cost-effective after colon adenoma removal

NEW YORK (Reuters Health) - 23/9/2019

For patients with adenomas removed during colon cancer screening, surveillance colonoscopy three to five years later provides clinically meaningful benefits and is cost-effective, a U.S. modeling study shows.

Anti-TNF treatment tied to lower risk of acute arterial events in IBD

NEW YORK (Reuters Health) - 23/9/2019

Anti-tumor necrosis factor (TNF) treatment is associated with a reduced risk of acute arterial events in patients with inflammatory bowel disease (IBD), especially men, new research shows.

'Silent' celiac disease common in patients' close relatives

(Reuters Health) - 23/9/2019

When a family member has celiac disease, Mayo Clinic researchers recommend parents, siblings and children also be tested, after a new study suggests first-degree relatives frequently have the condition, too - often without typical symptoms.

Less peripheral sensory neuropathy with shorter-term oxaliplatin-based chemotherapy

NEW YORK (Reuters Health) - 20/9/2019

Patients with advanced colon cancer face a lower risk of developing long-term peripheral sensory neuropathy (PSN) with a three-month rather than a six-month regimen of oxaliplatin-based adjuvant chemotherapy, according to results from the ACHIEVE phase 3 trial.

Anti-EGFR therapy appears beneficial in colorectal cancer with class-3 BRAF mutations

NEW YORK (Reuters Health) - 19/9/2019

Metastatic colorectal cancer with class-3 BRAF mutations is likely to respond to anti-EGFR therapy, whereas cancers with class-2 BRAF mutations are unlikely to respond, suggests an analysis of databases and electronic records.

Mirikizumab appears effective in moderate to severe ulcerative colitis

NEW YORK (Reuters Health) - 13/9/2019

Mirikizumab may be effective for inducing clinical remission and response and endoscopic improvement in patients with ulcerative colitis (UC), according to a new phase-2 study.

TNF inhibitors do not up risk of serious infection in kids with IBD

NEW YORK (Reuters Health) - 12/9/2019

The use of tumor necrosis factor (TNF)-alpha inhibitors is not associated with an increased risk of serious infection in children with inflammatory bowel disease (IBD), according to data from Denmark.

Better outcomes seen with early restart of anticoagulants after GI bleeding

NEW YORK (Reuters Health) - 10/9/2019

Early resumption of anticoagulant or antiplatelet therapy after a gastrointestinal bleeding event is associated with better outcomes overall, researchers in Spain report.

Colorectal cancer becoming more common at younger ages

(Reuters Health) - 9/9/2019

Rates of early-onset colon cancer are rising in many high-income countries even as rates among older adults hold steady or decline, a new study shows.

Histopathologic scores unreliable for fibromuscular stenosis in CD

NEW YORK (Reuters Health) - 9/9/2019

Available histologic scoring systems to assess small bowel fibrosis in Crohn's disease (CD) have not been validated or tested for reliability, a systematic review reveals. A new scoring system is currently in development.

Undiagnosed celiac disease linked to unexplained behavioral problems in kids

NEW YORK (Reuters Health) - 6/9/2019

Subclinical celiac disease autoimmunity (CDA) is associated with anxiety and oppositional defiant behavior in children without a formal diagnosis of celiac disease, new research indicates.

Integrative surgical management may benefit patients with gut failure

NEW YORK (Reuters Health) - 4/9/2019

Integrative surgical management, including transplantation where appropriate, may benefit people with gut failure, according to one center's experience with 500 patients.

In ileal Crohn's disease, cell signature correlates with resistance to therapy

NEW YORK (Reuters Health) - 3/9/2019

A cell signature present at ileal Crohn's disease (iCD) diagnosis is associated with resistance to standard anti-TNF therapy, researchers say.

More GI symptoms from oral immunotherapy with higher baseline eosinophil counts

NEW YORK (Reuters Health) - 2/9/2019

Higher baseline absolute eosinophil counts (AECs) are associated with an increased risk of oral-immunotherapy-induced gastrointestinal symptoms and eosinophilic responses (OITIGER), researchers from Israel report.

More fruit and cereal fiber tied to less risk of common bowel disease

(Reuters Health) - 29/8/2019

Women who get more fiber from fruits and cereals may be less like to develop diverticulitis, a common and painful bowel problem, though vegetable sources of fiber don't make much difference, a U.S. study suggests.

Tumor seeding during colonoscopy linked to metachronous colorectal cancer

NEW YORK (Reuters Health) - 28/8/2019

Tumor seeding may occur during colonoscopy, although the risk is low, a proof-of-principle study reveals.

GERD a risk factor for temporomandibular joint disorders

NEW YORK (Reuters Health) - 22/8/2019

Gastroesophageal reflux disease (GERD) is associated with a nearly three-fold increased risk of temporomandibular disorders (TMD), according to a new case-control study.

Pregnancy after bariatric surgery linked to adverse perinatal outcomes

NEW YORK (Reuters Health) - 21/8/2019

Pregnancy after bariatric surgery is associated with increases in some adverse perinatal outcomes, according to a new systematic review and meta-analysis.

Risk of late adverse events 'non-negligible' with bariatric surgery

NEW YORK (Reuters Health) - 20/8/2019

Bariatric surgery reduces long-term mortality in obese patients, but also carries a "significantly high" risk of late adverse events, according to new research.

UC disease course similar for smokers, non-smokers

NEW YORK (Reuters Health) - 16/8/2019

A new study adds to evidence that smoking does not improve disease outcomes in ulcerative colitis (UC) and that kicking the habit will not worsen the disease, as some have thought.

Bowel preparation does not reduce morbidity of elective colectomy

NEW YORK (Reuters Health) - 16/8/2019

Mechanical and oral antibiotic bowel preparation (MOABP) does not reduce surgical site infections (SSIs) or overall morbidity after elective colectomy, compared with no bowel preparation, according to results from the MOBILE trial.

Different presentation leads to later colorectal-cancer diagnosis in people under 50

NEW YORK (Reuters Health) - 15/8/2019

Presentation with nonspecific symptoms contributes to delays in the diagnosis of colorectal cancer in patients younger than 50, researchers in the U.K. report.

Early gluten intake tied to celiac risk in predisposed children

NEW YORK (Reuters Health) - 13/8/2019

Higher gluten intake during the first five years of life appears to be associated with an increased risk of celiac disease autoimmunity and celiac disease in genetically predisposed children, according to findings from the TEDDY study group.

Diabetes linked to increased risk of gastric cancer after H. pylori eradication

NEW YORK (Reuters Health) - 8/8/2019

Diabetes appears to increase the risk of gastric cancer after Helicobacter pylori eradication, especially in patients with suboptimal glycemic control, according to a database study.

Prehabilitation before colorectal cancer surgery might prolong disease-free survival

NEW YORK (Reuters Health) - 8/8/2019

A month of prehabilitation before colorectal cancer is associated with higher disease-free survival (DFS) rates, according to a pooled analysis of three studies.

Patient-clinician toolkit can ease transition from pediatric to adult IBD care

NEW YORK (Reuters Health) - 7/8/2019

A toolkit created by a patient-clinician team can facilitate the transition from pediatric to adult care for adolescents with inflammatory bowel disease (IBD), according to the tool's developers.

Biomarkers can help predict response to immune-checkpoint blockade in GI cancer

NEW YORK (Reuters Health) - 1/8/2019

Serological markers can help predict how patients with metastatic gastrointestinal-tract cancer will respond to immune-checkpoint blockade (ICB), according to Chinese researchers.

Gastric acid inhibitors tied to increased risk for developing allergies

NEW YORK (Reuters Health) - 31/7/2019

Gastric acid inhibitors increase the risk of developing allergies, according to an analysis of more than eight million health records from Austria.

Mesenchymal-stromal-cell therapy effective long-term for Crohn's disease perianal fistulas

Source: Reuters - 26/7/2019

Most patients with Crohn's disease whose perianal fistulas close after allogeneic bone marrow-derived mesenchymal stromal cell (bmMSC) therapy remain fistula-free four years later, researchers from the Netherlands report.

Vedolizumab brings endoscopic remission in some patients with Crohn's disease

Source: Reuters - 22/7/2019

About 1 patient in 8 experiences endoscopic remission of Crohn's disease after completing 26 weeks of treatment with the gut-selective monoclonal antibody vedolizumab, according to results from a phase 3b single-group study.

More people developing colorectal cancer before age 50

Source: Reuters - 22/7/2019

More people in the US are developing colorectal cancer before age 50, a trend that has also been seen in Europe.

Intestinal fibrosis in IBD hard to diagnose, treat

NEW YORK (Reuters Health) - 19/7/2019

Intestinal fibrosis in patients with inflammatory bowel disease (IBD) is challenging to diagnose, and there are no approved antifibrotic therapies, according to a meeting summary.

Epithelial response to butyrate diminished in active IBD

NEW YORK (Reuters Health) - 18/7/2019

The epithelial response to butyrate in patients with inflammatory bowel disease (IBD) is diminished, but only in the presence of tumor necrosis factor alpha (TNFalpha), researchers from Spain report.

Colonoscopy modifications don't improve detection of serrated adenoma

NEW YORK (Reuters Health) - 17/7/2019

Distal attachments or electronic chromoendoscopy do not generally improve detection of serrated adenomas during colonoscopy, according to pooled data from 17 randomized trials.

Less positive emotional-recognition bias linked to depression in IBD

NEW YORK (Reuters Health) - 12/7/2019

Depression in people with inflammatory bowel disease (IBD) is associated with less positive emotional-recognition bias, researchers from the U.K. report.

Anti-TNF alpha agents tied to increased IBD risk

NEW YORK (Reuters Health) - 11/7/2019

Patients being treated with anti-TNF alpha agents, particularly etanercept, for autoimmune diseases such as rheumatoid arthritis (RA) are at increased risk of developing inflammatory bowel disease (IBD), according to a Danish population-based study.

Diverting loop ileostomy increasingly used to manage fulminant C difficile colitis

NEW YORK (Reuters Health) - 11/7/2019

Diverting loop ileostomy (LI) is increasingly favored over total abdominal colectomy (TAC) for the surgical management of patients with fulminant Clostridium difficile colitis, according to a new study.

PPI, H2RA equally good at preventing bleeding recurrence in H. pylori-negative ulcers

NEW YORK (Reuters Health) - 10/7/2019

Lansoprazole and famotidine have comparable effects in preventing recurrent idiopathic gastroduodenal ulcer bleeding, a two-year randomized clinical trial shows.

Colorectal cancer rates up in younger European adults

NEW YORK (Reuters Health) - 9/7/2019

The incidence of colorectal cancer is increasing among European adults aged 20-49 years, broadly in parallel with trends already documented in 20- to 40-year-olds in North America, Australia and China, according to new findings.

Nutritional approach brings sustained remission in Crohn's disease

NEW YORK (Reuters Health) - 5/7/2019

The combination of an exclusion diet plus partial enteral nutrition (PEN) induces sustained remission in children with mild-to-moderate Crohn's disease, according to results from a randomized controlled trial.

Gastric cancer risks due to CDH1 variant likely overestimated

NEW YORK (Reuters Health) - 4/7/2019

The cumulative incidence of gastric cancer for individuals with a pathogenic CDH1 variant is lower than previously reported, according to a recent retrospective analysis.

Lower risk of reintervention after sleeve gastrectomy versus gastric bypass

NEW YORK (Reuters Health) - 1/7/2019

Sleeve gastrectomy (SG) conferred a significantly lower risk of reintervention at five years compared to Roux-en-Y gastric bypass (RYGB) in a retrospective analysis of patients who underwent the procedures between 2005 and 2015.

Obese patients save money on meds after bariatric surgery

NEW YORK (Reuters Health) - 26/6/2019

Obese patients spend less on diabetes and hypertension medications after bariatric surgery, according to new research.

Proactive drug monitoring improves outcomes in kids with Crohn’s

NEW YORK (Reuters Health) - 25/6/2019

Proactive therapeutic-drug monitoring (TDM) in children with Crohn's disease on adalimumab reduces clinical exacerbations compared to reactive TDM, a randomized controlled trial shows.

Vitamin deficiencies may be the only sign of celiac disease

(Reuters Health) - 25/6/2019

Adults with undiagnosed celiac disease often have nutrient deficiencies as the only sign of the condition, researchers say.

Primary anastomosis better than Hartmann's procedure for treating perforated diverticulitis

NEW YORK (Reuters Health) - 24/6/2019

For stable patients with perforated diverticulitis and peritonitis, sigmoidectomy with primary anastomosis provides better outcomes than does Hartmann's procedure, according to results from the LADIES trial.

Peritoneal carcinomatosis profiles highlight gastric cancer targets

NEW YORK (Reuters Health) - 20/6/2019

Sequencing of whole exome and transcriptome of peritoneal carcinomatosis (PC) in patients with gastric adenocarcinoma (GAC) has given novel insights and opened up new therapeutic opportunities, according to Texas-based researchers.

Anti-TNF therapy for IBD can be safely stopped before third trimester

NEW YORK (Reuters Health) - 19/6/2019

Anti-tumor necrosis factor (TNF) therapy in pregnant women with inflammatory bowel disease (IBD) can be discontinued before week 30 of gestation without increasing relapse risk or harming the fetus, researchers report.

Low-FODMAP diet has little effect on micronutrients intake in short term

NEW YORK (Reuters Health) - 18/6/2019

Following a low-FODMAP diet for a limited period appears not to reduce the mean daily intake of most micronutrients in adults with irritable bowel syndrome (IBS) with diarrhea, a new study suggests.

No reductions in IBD hospitalizations, surgeries after infliximab approval in Canada

NEW YORK (Reuters Health) - 17/6/2019

Introduction of infliximab, the first biologic therapy approved for inflammatory bowel disease (IBD) in Canada, did not lead to lower rates of hospitalizations or intestinal surgeries for the disorder in Ontario, researchers say.

Half of severely obese GERD patients still have reflux after surgery

NEW YORK (Reuters Health) - 14/6/2019

Gastric-bypass surgery leads to rapid improvement in reflux symptoms in obese patients with gastroesophageal reflux (GERD), but about half still need anti-reflux medication afterwards, new research shows.

Colorectal-tumor screening for Lynch syndrome has low yield in elderly

NEW YORK (Reuters Health) - 12/6/2019

The diagnostic yield of universal screening of colorectal tumors for Lynch syndrome decreases substantially after ages 70 to 75, a retrospective study suggests.

Inflammatory bowel disease patients have higher health costs

(Reuters Health) - 7/6/2019

People with inflammatory bowel disease (IBD) - either Crohn's disease or ulcerative colitis - may incur health costs more than three times higher than individuals without these conditions, a U.S. study suggests.

Laparoscopic on par with open surgery for colorectal-cancer liver metastases

NEW YORK (Reuters Health) - 5/6/2019

Laparoscopic surgery is just as effective long-term as open surgery for patients undergoing removal of colorectal cancer that has spread to the liver, according to results of the OSLO-COMET study.

Vedolizumab likely unhelpful for extra-intestinal manifestations of IBD

NEW YORK (Reuters Health) - 3/6/2019

There is "no strong evidence" to suggest that vedolizumab can treat pre-existing extra-intestinal manifestations (EIMs) of inflammatory bowel disease (IBD), although the drug may reduce the occurrence of new ones, a systematic review suggests.

Fixed-dose enoxaparin prophylaxis often inadequate for colorectal surgery

NEW YORK (Reuters Health) - 30/5/2019

Most patients undergoing colorectal surgery don't get adequate anticoagulation from the FDA-approved 40 mg daily dose of enoxaparin, possibly setting the stage for breakthrough venous thromboembolism, researchers say.

Early endoscopic remission linked to altered course of Crohn's disease

NEW YORK (Reuters Health) - 29/5/2019

Patients with early Crohn's disease who achieve endoscopic or deep remission after one year of intensive treatment are less likely to experience disease progression over the next several years, new research shows.

Laparoscopic gastrectomy effective for locally advanced gastric cancer

NEW YORK (Reuters Health) - 29/5/2019

Laparoscopic gastrectomy is noninferior to open distal gastrectomy in patients with locally advanced gastric cancer, researchers from China report.

IBS patients found to have atypical food allergies

NEW YORK (Reuters Health) - 29/5/2019

A confocal laser endomicroscopy (CLE) analysis of patients with irritable bowel syndrome (IBS) revealed that more than half may have atypical, IgE-negative food allergies.

Perioperative FLOT chemotherapy improves survival with gastric cancer

NEW YORK (Reuters Health) - 27/5/2019

Perioperative chemotherapy with fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT) improves survival in patients with locally advanced resectable gastric adenocarcinoma, according to results from the FLOT4-AIO trial.

Machine-learning models help predict remission in Crohn's

NEW YORK (Reuters Health) - 23/5/2019

Machine learning models can help identify patients with Crohn's disease likely to be durable responders to ustekinumab before committing to long-term treatment, researchers report.

Overall diet quality in many with IBS is poor

NEW YORK (Reuters Health) - 23/5/2019

Many people with irritable bowel syndrome (IBS) don't get the nutrition they need, according to new research from the United Kingdom.

Hypoalbuminemia linked to worse outcomes after IBD surgery

NEW YORK (Reuters Health) - 15/5/2019

Hypoalbuminemia is associated with worse mortality and complication rates after major abdominal surgery related to inflammatory bowel disease (IBD), according to a database study.

Endoscopic sleeve gastroplasty linked to lasting weight loss without surgery

NEW YORK (Reuters Health) - 15/5/2019

Endoscopic sleeve gastroplasty was associated with significant weight loss in the first long-term study to follow patients over five years, report researchers from NewYork-Presbyterian/Weill Cornell Medical Center.

Novel test predicts IBD course at diagnosis

NEW YORK (Reuters Health) - 13/5/2019

A 17-gene classifier can predict the course of inflammatory bowel disease (IBD) at diagnosis, helping to set the stage for personalized therapy, researchers in the UK say.

Breath analysis shows promise in distinguishing IBD types

NEW YORK (Reuters Health) - 9/5/2019

A breath analyzer can identify inflammatory bowel disease (IBD) in affected individuals and distinguish ulcerative colitis (UC) from Crohn's disease (CD), a pilot study reveals.

IBD transition coordinator may help adolescents switch to adult care

NEW YORK (Reuters Health) - 6/5/2019

A one-time intervention by an inflammatory bowel disease (IBD) transition coordinator appears to improve adolescent patients' self-management skills and readiness to transition to adult care, according to a retrospective chart review.

Laparoscopic surgery effective for chronic reflux-linked cough

NEW YORK (Reuters Health) - 3/5/2019

Laparoscopic antireflux surgery (LARS) is an effective treatment for chronic cough associated with gastroesophageal reflux disease, with three-quarters of patients having complete resolution of symptoms, researchers report.

Ustekinumab beneficial in refractory Crohn's disease in real world

NEW YORK (Reuters Health) - 30/4/2019

A real-world observational study confirms the benefit of ustekinumab in patients with Crohn's disease (CD) previously exposed to other biologics, according to Belgian researchers.

Immunosuppressants found safe for IBD patients with cancer history

NEW YORK (Reuters Health) - 30/4/2019

Immunosuppressant therapies (IMTs) do not appear to increase the risk of new or recurrent cancers in inflammatory bowel disease (IBD) patients with a history of cancer unrelated to immunosuppression, new findings show.

Bismuth quadruple therapy best for H. pylori eradication

NEW YORK (Reuters Health) - 26/4/2019

In settings where susceptibility data are hard to come by, 14 days of bismuth quadruple therapy is likely best for Helicobacter pylori eradication, researchers report.

Primary anastomosis with diverting loop ileostomy for acute diverticulitis found safe

NEW YORK (Reuters Health) - 24/4/2019

Primary anastomosis with diverting loop ileostomy (PADLI) is a safe alternative to Hartmann's procedure (HP) for emergency management of patients with acute diverticulitis, researchers report.

Gene signature linked to survival after pancreatic-cancer surgery

NEW YORK (Reuters Health) - 23/4/2019

In patients with pancreatic ductal adenocarcinoma (PDAC) presence of two single-nucleotide polymorphisms (SNPs) may help predict surgical outcome, according to European researchers.

MR enterography best identifies fibrotic vs inflammatory strictures in Crohn's disease

NEW YORK (Reuters Health) - 23/4/2019

Conventional imaging techniques accurately detect strictures in patients with Crohn's disease, but magnetic resonance enterography (MRE) best differentiates fibrotic from inflammatory components, researchers say.

IBD patients who switch from infliximab to biosimilar see mixed results

NEW YORK (Reuters Health) - 23/4/2019

Patients with inflammatory bowel disease (IBD) can safely switch from infliximab to the biosimilar CT-P13, though they may face a higher risk of clinical relapse, researchers from Spain report.

Therapy by phone or web improves patient-reported outcomes in IBS

NEW YORK (Reuters Health) - 23/4/2019

Cognitive behavioral therapy (CBT) delivered by phone or online leads to improvements in patient-reported outcomes in irritable bowel syndrome (IBS), according to a clinical trial from the U.K.

Certain factors predict celiac disease risk in children with positive serology but negative biopsy

NEW YORK (Reuters Health) - 23/4/2019

In children with "potential" celiac disease - positive serology but negative biopsy - who are not on gluten-free diets, factors that may help predict risk for eventual villous atrophy include age at diagnosis, gamma delta lymphocytes and HLA haplotype, researchers say.

IBD survey accurately captures patient-reported symptoms

NEW YORK (Reuters Health) - 12/4/2019

The Inflammatory Bowel Disease (IBD) Symptom Inventory accurately captures patient-reported symptoms and can be used to monitor patients in clinic or research settings, researchers from Canada report.

Esophageal reflux common after sleeve gastrectomy

NEW YORK (Reuters Health) - 12/4/2019

About one in four patients will develop gastroesophageal reflux disease (GERD) after sleeve gastrectomy, but few will require conversion to gastric bypass for severe reflux, according to a systematic review and meta-analysis.

Endoscopic surveillance finds unsuspected carcinomas in predisposed individuals

NEW YORK (Reuters Health) - 10/4/2019

Endoscopic surveillance can identify unsuspected signet-ring-cell carcinoma in individuals predisposed to hereditary diffuse gastric cancer (HDGC) by virtue of pathogenic variants in CDH1, researchers report.

Infliximab biosimilar CT-P13 noninferior in active Crohn's disease

NEW YORK (Reuters Health) - 9/4/2019

The infliximab biosimilar CT-P13 is noninferior to infliximab for treating patients with active Crohn's disease, according to a randomized controlled trial.

Colorectal cancer screening beginning at age 45 years could be cost-effective

NEW YORK (Reuters Health) - 5/4/2019

Colorectal cancer (CRC) screening beginning at age 45 years instead of 50 years for average-risk individuals is likely cost-effective, researchers report.

Endoscopic clip closure after large polyp resection in right colon reduces bleeding

NEW YORK (Reuters Health) - 3/4/2019

Endoscopic clip closure after resection of large sessile polyps in the proximal colon reduced the risk of post-procedure bleeding in a multicenter randomized trial, researchers say.

New monitoring system reduces blind spots during esophagogastroduodenoscopy

NEW YORK (Reuters Health) - 1/4/2019

The new WISENSE monitoring system reduces blind-spot rates during esophagogastroduodenoscopy (EGD), researchers from China report.

Glepaglutide treatment promising in short-bowel syndrome

NEW YORK (Reuters Health) - 29/3/2019

The novel long-acting glucagon-like peptide-2 analogue glepaglutide appears to improve intestinal function in patients with short-bowel syndrome, according to a small randomized trial.

Similar participation rates with 2 brands of fecal immunochemical test

NEW YORK (Reuters Health) - 28/3/2019

Two brands of fecal immunochemical tests (FITs), FOB-Gold and OC-Sensor, are associated with similar colorectal cancer (CRC) screening participation despite small differences in ease of use, Dutch researchers report.

Reduced-dose combo treatment helps some with metastatic colorectal cancer

NEW YORK (Reuters Health) - 26/3/2019

Reduced-dose combination chemotherapy improves progression-free survival, compared with full-dose monotherapy, in older vulnerable patients with metastatic colorectal cancer (CRC), according to results from the phase II NORDIC9 trial.

Partial fundoplication may have edge in treating GERD

NEW YORK (Reuters Health) - 15/3/2019

In surgical treatment of gastroesophageal reflux disease (GERD), partial fundoplication (PF) prompts less dysphagia than total fundoplication (TF), according to randomized trial results reported by Scandinavian researchers.

Optical technologies unreliable at diagnosing pre-cancerous colorectal polyps

NEW YORK (Reuters Health) - 14/3/2019

The accuracy of optical technologies in differentiating cancerous from benign tissue is "insufficient" for most routine clinical applications, including diagnosing pre-cancerous colorectal polyps, researchers say.

Early-onset colorectal cancer has distinct clinical and genetic features

NEW YORK (Reuters Health) - 13/3/2019

Colorectal cancer that is diagnosed before age 50 has clinical and genetic features that differ from those seen in colorectal cancer diagnosed later in life, according to new research.

T cell clonal expansion linked to postop recurrence of Crohn's in smokers

NEW YORK (Reuters Health) - 11/3/2019

Among smokers with Crohn's disease, increased T cell clonal expansion, especially in the CD8 compartment, is exaggerated and is associated with an increased rate of disease recurrence after ileocolonic resection, according to results from the REMIND Study Group.

Extended lymph node dissection safe in gastroesophageal carcinoma

NEW YORK (Reuters Health) - 8/3/2019

Extended lymphadenectomy (LAD) to improve staging accuracy for gastroesophageal carcinoma (GEC) can be done safely, according to a new case series.

Misdiagnosis of young-onset colorectal cancer common

NEW YORK (Reuters Health) - 7/3/2019

Many patients younger than age 50 who develop colorectal cancer are initially misdiagnosed, leading to a more advanced stage of disease when it is detected, according to a new study.

New risk score helps predict intra-abdominal abscess in Crohn's disease

NEW YORK (Reuters Health) - 5/3/2019

A new, five-parameter risk score accurately predicts intra-abdominal abscess in Crohn's disease (CD) patients presenting to the emergency department (ED), researchers from Israel report.

Beta-cell sensitivity reduced after gastric bypass surgery

NEW YORK (Reuters Health) - 4/3/2019

After gastric bypass surgery, beta-cells in nondiabetic patients are less sensitive to insulinotropic gut hormones, researchers report.

Model finds bariatric surgery cost-effective in NASH

NEW YORK (Reuters Health) - 1/3/2019

Bariatric surgery could extend life expectancy and quality-adjusted life-years (QALY) cost-effectively in overweight and obese patients with nonalcoholic steatohepatitis (NASH), a new modeling study suggests.

Sleeve gastrectomy may be safer than gastric bypass for IBD patients

NEW YORK (Reuters Health) - 28/2/2019

Most obese patients with inflammatory bowel disease (IBD) fare well after bariatric surgery, but gastric bypass could make Crohn's disease harder to control, new research suggests.

Fecal immunochemical tests useful for colorectal-cancer screening

NEW YORK (Reuters Health) - 26/2/2019

One-time fecal immunochemical tests (FIT) can be useful for identifying colorectal cancer (CRC), but they lack sensitivity for advanced adenomatous polyps, according to a systematic review and meta-analysis.

Weight-loss surgery can bring lasting improvement in sexual function

(Reuters Health) - 22/2/2019

Weight-loss surgery has more benefits than simply slimming a patient down, it may also result in lasting improvements to sexual functioning, a new study suggests.

High-fat diet adversely affects gut microbiota

By Will Boggs MD - 22/2/2019

Higher-fat diets have unfavorable effects on gut microbiota, fecal metabolites and plasma proinflammatory factors, researchers from China report.

Routine diversion after sphincter-sparing rectal surgery tied to poorer outcomes

NEW YORK (Reuters Health) - 22/2/2019

Routine diversion after sphincter-sparing rectal cancer resection does not reduce anastomotic leaks and is associated with more reinterventions, readmissions, and higher costs, according to a database study.

Treg cells show promise as immunotherapy for Crohn's disease

NEW YORK (Reuters Health) - 13/2/2019

Crohn's disease (CD) symptoms may be reduced if an agonist of the retinoic acid receptor alpha (RARA) can be used to traffic T-regulatory (Treg) cells to inflamed intestinal tissues, researchers suggest.

Laparoscopic gastrectomy outcome comparable to open surgery

NEW YORK (Reuters Health) - 13/2/2019

Patients with stage I gastric cancer who undergo laparoscopic distal gastrectomy have long-term-survival rates similar to those who have open distal gastrectomy, according to a clinical trial from South Korea.

Heavier red meat consumption tied to higher NAFLD risk

(Reuters Health) - 13/2/2019

People who eat a lot of animal protein may be more likely to have excessive fat in their livers and a higher risk of non-alcoholic fatty liver disease (NAFLD) than individuals whose main source of protein is vegetables, a Dutch study suggests.

GLP-1 enhances insulin secretion after bariatric surgery

NEW YORK (Reuters Health) - 12/2/2019

Glucagon-like peptide 1 (GLP-1) plays a major role in driving enhanced insulin secretion following bariatric surgery, researchers from the U.K. report.

Surgery may curb risk of recurrent adhesive small-bowel obstruction

NEW YORK (Reuters Health) - 8/2/2019

Surgical intervention reduces the risk that adhesive small-bowel obstruction (aSBO) will recur, whether it's done at the index episode or during recurrent episodes, researchers say.

Aspirin, anticoagulants up rate of false positives with FIT for colorectal cancer

NEW YORK (Reuters Health) - 7/2/2019

Regular use of aspirin or anticoagulants reduces the positive predictive value (PPV) of fecal immunochemical testing (FIT) for detecting colorectal cancer and advanced adenomas, researchers from Norway report.

Collagen signature helps predict lymph-node metastasis in gastric cancer

NEW YORK (Reuters Health) - 7/2/2019

In patients with early gastric cancer the collagen signature in the tumor microenvironment is an independent indicator of lymph-node metastasis, according to Chinese researchers.

Recurrence risk constant after ablation in Barrett's esophagus

NEW YORK (Reuters Health) - 5/2/2019

Diligent surveillance remains important after remission of intestinal metaplasia (CRIM) following radiofrequency ablation (RFA) in Barrett's esophagus, researchers say.

Multiple infliximab doses better for acute severe ulcerative colitis

NEW YORK (Reuters Health) - 1/2/2019

As salvage therapy for acute severe ulcerative colitis refractory to corticosteroids, multiple infliximab doses are superior to a single dose for improving colectomy-free survival, according to a new systematic review and meta-analysis.

Glycemic control tied to better outcome of anti-VEGF therapy for diabetic macular edema

NEW YORK (Reuters Health) - 1/2/2019

Strong glycemic control may optimize vision outcomes in patients with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (anti-VEGF) therapy, researchers say.

Azathioprine ups pancreatitis risk in pediatric IBD

NEW YORK (Reuters Health) - 31/1/2019

Azathioprine is associated with a six-fold increased risk of acute pancreatitis in children with inflammatory bowel disease (IBD), new research shows.

Adding vedolizumab to steroids may boost response, remission in Crohn's disease

NEW YORK (Reuters Health) - 30/1/2019

In patients with moderate to severe Crohn's disease who've been taking stable doses of steroids, adding vedolizumab may help induce a clinical response or remission, researchers say.

Postpartum substance abuse, mood disorders more common with IBD

NEW YORK (Reuters Health) - 25/1/2019

Inflammatory bowel disease (IBD), and Crohn's disease in particular, is associated with an increased risk of postpartum mood disorders and substance abuse, new findings in the journal Gut show.

Soluble fiber may improve diabetes control

(Reuters Health) - 24/1/2019

People with diabetes who take soluble fiber supplements have slightly lower blood sugar than their peers who don't add this type of fiber to their diets, a research review finds.

Younger, more insulin-sensitive T2DM patients benefit most from intensive insulin

NEW YORK (Reuters Health) - 23/1/2019

Patients with newly diagnosed type 2 diabetes can experience long-term glycemic remission with intensive insulin treatment - but this effect is more likely in younger patients and those with lower post-treatment glucose levels, according to new findings in the Journal of Clinical Endocrinology and Metabolism.

NAFLD in adolescent boys improves with low sugar diet

NEW YORK (Reuters Health) - 22/1/2019

Adolescent boys on a "low free sugar" diet show significant improvements in nonalcoholic fatty liver disease (NAFLD), according to results from an 8-week randomized clinical trial.

Hyperglycemia tied to higher fracture risk in elderly Japanese men

NEW YORK (Reuters Health) - 17/1/2019

Community-dwelling elderly men with hyperglycemia are at elevated risk of osteoporotic fracture, according to Japanese researchers.

Fecal-microbiota transplant boosts ulcerative colitis remission

NEW YORK (Reuters Health) - 16/1/2019

Anaerobically prepared fecal-microbiota transplantation (FMT) improved remission rates in adults with mild to moderate ulcerative colitis (UC) in a randomized trial.

Fecal-microbiota transplant beats antibiotics for recurrent C diff

NEW YORK (Reuters Health) - 16/1/2019

Fecal-microbiota transplantation (FMT) is superior to 10 days of fidaxomicin or vancomycin for resolving recurrent Clostridium difficile infection (CDI), according to results from a randomized open-label clinical trial.

Serology an increasingly important indicator of celiac disease

NEW YORK (Reuters Health) - 9/1/2019

Serology has gained importance in the diagnosis of celiac disease (CD), due to improvements in assay performance over the last decade, according to updated advice for clinical practice.

Complications fewer, survival unaffected by less-invasive esophageal cancer surgery

(Reuters Health) - 9/1/2019

In patients with esophageal cancer, laparoscopic abdominal surgery combined with an open thoracotomy - i.e., hybrid minimally invasive esophagectomy - produces 77% fewer major complications than open esophagectomy without lowering survival, according to a study of more than 200 French patients reported January 9 online in The New England Journal of Medicine.

Advanced endoscopic techniques improve IBD assessment

NEW YORK (Reuters Health) - 8/1/2019

Advanced endoscopic techniques allow for better assessment of mucosal healing and dysplasia in patients with inflammatory bowel disease (IBD), according to a new review.

Need for bariatric revision varies by primary operation

NEW YORK (Reuters Health) - 2/1/2019

Bariatric reoperations are more common after banding and vertical banded gastroplasty (VBG) than after gastric bypass (GBP), according to long-term follow-up of participants in the Swedish Obese Subjects (SOS) study.

Haematology

Higher risk of hypertension, cardiovascular events seen with ibrutinib use

NEW YORK (Reuters Health) - 10/10/2019

Initiation of ibrutinib therapy is associated with an increased risk of hypertension and subsequent cardiovascular events, according to a database study.

Stroke rates continue to decline in the U.S.

(Reuters Health) - 9/10/2019

Rates of stroke among U.S. adults over age 65 have steadily decreased over the past 30 years, according to a study that tracked participants from the 1980s through December 2017.

Mortality from antineutrophil cytoplasmic autoantibody-associated vasculitis falling slightly

NEW YORK (Reuters Health) - 8/10/2019

Mortality rates in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) decreased from 1999 to 2017, according to records from the Centers for Disease Control and Prevention (CDC).

Ibrutinib linked to severe cardiac events

NEW YORK (Reuters Health) - 26/9/2019

Ibrutinib, a BTK inhibitor, is associated with severe and occasionally fatal cardiac events that should be discussed with patients and considered in clinical trial designs, a retrospective observational study reveals.

Questions linger about efficacy of thrombectomy, medical management in mild stroke

NEW YORK (Reuters Health) - 26/9/2019

Most outcomes appear to be similar with mechanical thrombectomy (MT) versus best medical management (bMM) in mild strokes due to emergency large-vessel occlusion (ELVO), but uncertainty remains, according to new findings.

Point-of-care testing useful for newborn sickle cell screening

NEW YORK (Reuters Health) - 17/9/2019

Point-of-care testing is useful for newborn screening for sickle cell disease (SCD) in low-income settings, according to results from an observational study.

Infectious diseases

London HIV patient becomes world's second AIDS cure hope

LONDON (Reuters) - 5/3/2019

An HIV-positive man in Britain has become the second known adult worldwide to be cleared of the AIDS virus after he received a bone marrow transplant from an HIV resistant donor, his doctors said.

Measles vaccine not linked with autism in high-risk kids

(Reuters Health) - 5/3/2019

The measles, mumps and rubella (MMR) vaccine isn't associated with an increased risk of autism even among kids who are at high risk because they have a sibling with the disorder, a Danish study suggests.

Stopping oral antiviral therapy in chronic hep B possible for some people

NEW YORK (Reuters Health) - 4/3/2019

A new analysis provides insight into what happens after stopping tenofovir disoproxil fumarate (TDF) in chronic hepatitis B patients with persistent viral suppression who took the drug for at least eight years.

Low rates of viral suppression among young black men with HIV

NEW YORK (Reuters Health) - 1/3/2019

Young black men with HIV have far lower rates of viral suppression than others with HIV, according to results from the Medical Monitoring Project (MMP).

Oncology

Multigene testing for all breast cancer patients cost-effective for UK, US: study

NEW YORK (Reuters Health) - 11/10/2019

Expanding genetic testing to all women with breast cancer is "extremely" cost-effective for the US and UK and could prevent thousands of breast or ovarian cancers and deaths, researchers say.

Australian clinicians uncertain about managing risk-reducing bilateral salpingo-oophorectomy

NEW YORK (Reuters Health) - 10/10/2019

A survey of Australian healthcare professionals managing premenopausal women at high genetic risk for ovarian cancer revealed uncertainty surrounding risk-reducing bilateral salpingo-oophorectomy (RRBSO).

Several factors linked to outcomes of male breast cancer

NEW YORK (Reuters Health) - 10/10/2019

Several factors are independently associated with better or worse overall survival in men with breast cancer, according to new findings.

Biopsy mass spectrometry identifies malignant potential of thyroid nodules

NEW YORK (Reuters Health) - 9/10/2019

Mass-spectrometry imaging of fine-needle aspiration (FNA) biopsies can accurately identify the malignant potential of thyroid nodules, researchers report.

Men with BRCA2 mutations should be offered PSA screening, researchers say

NEW YORK (Reuters Health) - 4/10/2019

Men with mutations in BRCA2 have an increased risk of prostate cancer and should be offered prostate-specific antigen (PSA) screening, according to the team behind the IMPACT study.

Adjuvant chemotherapy may have benefits in early breast cancer with high recurrence score

NEW YORK (Reuters Health) - 3/10/2019

Adjuvant chemotherapy added to endocrine therapy for early breast cancer with a high 21-gene recurrence score (RS) may improve clinical outcomes, according to a secondary analysis of the TAILORx randomized clinical trial.

Head and neck melanomas increasing, especially among boys and young men

(Reuters Health) - 3/10/2019

Although relatively rare, head and neck melanomas have been on the rise in North America, increasing by more than 50% over two decades, researchers report.

Mohs surgery an option for early-stage invasive melanoma

NEW YORK (Reuters Health) - 3/10/2019

Mohs micrographic surgery (MMS) may be an effective alternative to wide margin excision (WME) for appropriately selected patients with early-stage invasive melanoma, a large retrospective study suggests.

Abemaciclib plus fulvestrant boosts breast-cancer survival in some

NEW YORK (Reuters Health) - 2/10/2019

Abemaciclib in combination with fulvestrant can increase overall survival in patients with HR-positive, ERBB2-negative (HER2-negative) advanced breast cancer that has progressed on endocrine therapy (ET), according to the Monarch 2 trial.

Blood test detects multiple cancer types with high degree of accuracy

NEW YORK (Reuters Health) - 1/10/2019

A blood test in development can screen for more than 20 types of cancer with a high degree of accuracy, according to new research.

Veliparib extends progression-free survival in ovarian cancer

NEW YORK (Reuters Health) - 1/10/2019

Adding veliparib to chemotherapy as first-line induction therapy and using it as maintenance therapy significantly prolongs progression-free survival in women with previously untreated stage III or stage IV high-grade serous ovarian carcinoma, a new clinical trial shows.

Checkpoint-inhibitor adverse events difficult to categorize

NEW YORK (Reuters Health) - 26/9/2019

Compared with the toxicities of standard chemotherapy, reactions to checkpoint inhibitors are markedly more heterogeneous and unpredictable, according to a small study.

Local therapy tied to longer survival in metastatic intrahepatic cholangiocarcinoma

NEW YORK (Reuters Health) - 19/9/2019

Liver-directed local therapy is associated with improved overall survival in adults with metastatic and intrahepatic cholangiocarcinoma, according to findings from the National Cancer Database (NCDB).

Some experimental cancer drugs kill by off-target effects

NEW YORK (Reuters Health) - 18/9/2019

Some cancer drug candidates in clinical trials kill tumor cells through off-target effects, rather than by interacting with their intended target, researchers say.

High-risk men might benefit from breast-cancer screening, research suggests

NEW YORK (Reuters Health) - 17/9/2019

Men at high risk of developing breast cancer might benefit from screening, a 12-year longitudinal study hints.

Men with BRCA mutations at increased risk of prostate cancer, study confirms

NEW YORK (Reuters Health) - 16/9/2019

Males who carry BRCA1 or BRCA2 mutations are at increased risk of prostate cancer (PC), a new prospective study confirms.

Hepatitis B core-related antigen levels linked to liver cancer risk

NEW YORK (Reuters Health) - 11/9/2019

Hepatitis B core-related antigen (HBcrAg) levels are an independent risk factor for liver cancer in patients with chronic HBV infection, a retrospective analysis reveals.

Risk calculators for prostate cancer surveillance validated

NEW YORK (Reuters Health) - 6/9/2019

Two prostate cancer risk calculators that estimate the probability of reclassification with or without biopsy were validated in five large cohorts, researchers say - but using the calculators in the clinic can be complicated.

ENZAMET results show benefit of adding enzalutamide for hormone-sensitive prostate cancer

(Reuters Health) - 4/9/2019

In men with metastatic hormone-sensitive prostate cancer, the oral androgen receptor inhibitor enzalutamide increased the estimated 3-year survival rate by 8 percentage points, doctors reported at the American Society of Clinical Oncology's annual meeting in Chicago and online in The New England Journal of Medicine.

Nivolumab plus ipilimumab beats sunitinib for advanced kidney cancer

NEW YORK (Reuters Health) - 30/8/2019

Nivolumab plus ipilimumab is more effective than sunitinib as first-line treatment for patients with advanced renal-cell carcinoma (RCC), according to an extended follow-up of the ongoing CheckMate 214 trial.

Roche immunotherapy Tecentriq gains European approval for breast cancer

ZURICH(Reuters) - 29/8/2019

Roche's Tecentriq (atezolizumab) has won European approval for use against a tough-to-treat breast cancer, helping the Swiss drugmaker to widen use of an immunotherapy that has so far been eclipsed in revenue terms by more-established rival medicines.

Older women have more complications from mastectomy with immediate breast reconstruction

NEW YORK (Reuters Health) - 29/8/2019

Postoperative-complication rates after mastectomy with immediate breast reconstruction are higher for women aged 65 years and older than for younger women, according to a database study.

Tandem autologous stem-cell transplant boosts event-free neuroblastoma survival

NEW YORK (Reuters Health) - 28/8/2019

Tandem autologous stem-cell transplant (ASCT) may provide better event-free survival (EFS) in patients with high-risk neuroblastoma, compared with single ASCT, a new clinical trial shows.

Targeted light-based therapy promising in prostate-cancer treatment

NEW YORK (Reuters Health) - 26/8/2019

Photothermal ablation of localized prostate tumors using gold-silica nanoshells is a promising targeted therapy with what appears to be a low risk of serious side effects, a pilot study suggests.

GSK builds oncology pipeline as drug shown to help myeloma patients

(Reuters) - 23/8/2019

GlaxoSmithKline said an experimental multiple myeloma treatment has shown a meaningful response in patients that have run out of three previous treatment options, in a boost for the British drugmaker's cancer drug business.

Aspirin, mortality link in breast cancer may depend on methylation of breast-cancer genes

NEW YORK (Reuters Health) - 22/8/2019

Prior to diagnosis, breast cancer-related genes appear to interact with aspirin in certain women and could influence survival, an observational study hints.

Weight loss doesn't improve breast cancer-related lymphedema

NEW YORK (Reuters Health) - 22/8/2019

In overweight breast cancer survivors, neither losing weight nor exercising at home improves lymphedema, a new study shows.

With HPV risk timeline, older women recognize need for cervical cancer screening

(Reuters Health) - 21/8/2019

When middle-aged women realize their cervical cancer risk from HPV lasts decades, more of them decide to get screened for this cancer than when they only know HPV has a role in cancer, without an explicit timeline, a small study found.

USPSTF expands BRCA-testing guidelines

NEW YORK (Reuters Health) - 20/8/2019

In an updated recommendation, the US Preventive Services Task Force (USPSTF) is expanding the population eligible for BRCA screening.

Worse short-term mortality among men with prostate cancer and cardiovascular disease

NEW YORK (Reuters Health) - 15/8/2019

Men with prostate cancer and pre-existing cardiovascular disease (CVD) have worse short-term mortality following treatment with oral androgen-signaling inhibitors than do similar men without CVD, according to a database study.

Better detection of clinically significant prostate cancer with MRI plus targeted biopsy

NEW YORK (Reuters Health) - 15/8/2019

Prebiopsy multiparametric magnetic resonance imaging (mpMRI) combined with targeted biopsy is associated with improved detection of clinically significant prostate cancer compared with transrectal ultrasonography-guided systemic biopsy alone, a systematic review and meta-analysis reveals.

Adjuvant chemoradiotherapy may boost endometrial-cancer survival

NEW YORK (Reuters Health) - 13/8/2019

Combined adjuvant chemotherapy and radiotherapy appear significantly more effective than pelvic radiotherapy alone for women with high-risk endometrial cancer, according to a post hoc analysis of the PORTEC-3 trial.

Genotyping panel accurately identifies biomarkers for solid cancers in plasma

NEW YORK (Reuters Health) - 12/8/2019

A highly sensitive cell-free DNA (cfDNA) sequencing-based method allows simultaneous determination of microsatellite instability (MSI) status and genomic biomarkers for solid cancers in plasma, researchers report.

Waterjet ablation effective for treating benign prostatic obstruction

NEW YORK (Reuters Health) - 9/8/2019

Waterjet ablation appears promising for relieving benign prostatic obstruction in men with small- to medium-sized glands, according to results from the French Aquablation Clinical Registry.

Dense breast notification laws not leading to more screening ultrasounds

Reuters Health - 8/8/2019

State laws requiring women with dense breasts to be told about the benefits of further imaging after mammography may not lead more women to get extra screening, a U.S. study suggests.

Obesity tied to worse perioperative outcomes of radical prostatectomy

NEW YORK (Reuters Health) - 8/8/2019

Obese men face higher odds of perioperative complications from radical prostatectomy, according to findings from a database study.

Pancreatic-cancer screening still a no-go, according to task force

NEW YORK (Reuters Health) - 6/8/2019

The U.S. Preventive Services Task Force (USPSTF) continues to advise against routine screening for pancreatic cancer in asymptomatic adults.

Elective node radiation appears more effective for nodal-recurrent prostate cancer

NEW YORK (Reuters Health) - 5/8/2019

Elective nodal radiotherapy (ENRT) appears to reduce relapses better than stereotactic body radiotherapy (SBRT) in men with nodal oligorecurrent prostate cancer, according to a retrospective analysis.

Nivolumab therapy tied to better long-term survival in some cancer patients

NEW YORK (Reuters Health) - 2/8/2019

Treatment with nivolumab (Opdivo, Bristol-Myers Squibb) is associated with improved long-term survival in certain heavily pretreated cancer patients, according to a secondary analysis of a clinical trial.

Neoadjuvant radiotherapy beneficial in resectable liver cancer with portal vein tumor thrombus

NEW YORK (Reuters Health) - 1/8/2019

Neoadjuvant three-dimensional conformal radiotherapy (RT) followed by hepatectomy boosts outcomes over those with hepatectomy alone in patients with resectable hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT), researchers from China report.

MRI bests systematic biopsies for diagnosing prostate cancer

NEW YORK (Reuters Health) - 31/7/2019

Magnetic resonance imaging (MRI) is better than systematic biopsies for diagnosing prostate cancer, thereby reducing redundant biopsies, a Cochrane review and meta-analysis revealed.

Ibrutinib-based therapy better than conventional treatment for CLL

(Reuters Health) - 31/7/2019

Among patients with untreated chronic lymphocytic leukemia (CLL) who lack a key mutation, therapy with a combination of ibrutinib and rituximab produces longer survival and progression-free survival than standard chemoimmunotherapy, according to the official findings of a phase 3 study published online July 31 in The New England Journal of Medicine.

BRCA2 mutations linked with non-Hodgkin's lymphoma in children

NEW YORK (Reuters Health) - 31/7/2019

BRCA2 mutations increase the risk for pediatric non-Hodgkin's lymphoma (NHL), researchers say, and survivors should be offered genetic counseling.

Second-generation assay more sensitive, less specific in ovarian-cancer detection

Source: Reuters - 26/7/2019

The MIA2G multivariate index assay (Overa, Vermillion) with subsequent risk stratification is a more sensitive method of predicting ovarian cancer than is ROMA, a currently used triage algorithm, according to a company-funded study.

Voice problems common, undertreated after thyroid cancer surgery

Source: Reuters - 26/7/2019

Patient-reported voice problems are prevalent after thyroid cancer surgery and should be part of the preoperative risk-benefit discussion and postoperative rehabilitation, researchers say.

Lymphedema after axillary node dissection linked with obesity, longer neoadjuvant chemo

Source: Reuters - 25/7/2019

Increasing body mass index and longer neoadjuvant chemotherapy (NAC) are associated with a higher risk of lymphedema in women who undergo axillary lymph node dissection, researchers say.

Fast MRI protocol accurately identifies prostate cancer at lower cost

NEW YORK (Reuters Health) - 19/7/2019

A fast MRI protocol can accurately identify prostate cancer in biopsy-naive men at lower cost with minimally increased biopsy rates, researchers from the Netherlands report.

Wide variability seen in number needed to biopsy for cutaneous melanoma

NEW YORK (Reuters Health) - 18/7/2019

The number needed to biopsy (NNB) for cutaneous melanoma varies widely worldwide, and while there isn't a single "ideal" NNB, optimal standards should be developed, researchers say.

Niraparib helps ovarian cancer patients live longer in late-stage study

(Reuters) - 16/7/2019

GlaxoSmithKline Plc's cancer treatment Zejula (niraparib) met the main goal of helping patients with ovarian cancer live longer without their disease worsening in a late-stage study, the company said on Monday.

Deep-learning tool can help individualize radiotherapy doses based on imaging

NEW YORK (Reuters Health) - 11/7/2019

A new deep-learning framework based on CT images can help predict treatment failure and allow individualization of radiotherapy doses, researchers report.

MRI helps decisions on lateral nodal disease in rectal cancer

NEW YORK (Reuters Health) - 10/7/2019

Primary and restaging MRI can help define the risk of lateral local recurrence - and the need for lateral lymph node dissection (LLND) - in patients with low rectal cancer after chemoradiotherapy or radiotherapy, according to a multinational study.

3D printed models may best CT/MRI for renal tumor localization

NEW YORK (Reuters Health) - 5/7/2019

Experienced surgeons had trouble identifying the locations of kidney tumors on 3-dimensional models based only on information from typical 2-dimensional preoperative imaging, a new study found. The authors say 3D models could improve surgical planning.

European urologists release position paper on immune checkpoint inhibitor toxicities

NEW YORK (Reuters Health) - 2/7/2019

The European Association of Urology (EAU) has issued a position paper on diagnosis and management of toxicities related to the use of immune checkpoint inhibitors (ICIs) in advanced cancer.

Lung-cancer screening may be warranted in bladder-cancer patients

NEW YORK (Reuters Health) - 2/7/2019

Patients with transitional-cell carcinoma of the bladder (TCC) are at elevated risk of lung cancer, according to a retrospective study of U.S. data by Israeli researchers.

Strategy helps identify candidates for supplemental breast imaging

NEW YORK (Reuters Health) - 2/7/2019

Breast-density notification combined with breast-cancer risk helps identify women at high risk of advanced breast cancer who might benefit from supplemental imaging, according to an analysis of Breast Cancer Surveillance Consortium (BCSC) registry data.

Decision aids for prostate-cancer screening of limited value

NEW YORK (Reuters Health) - 28/6/2019

Currently available decision aids for prostate-cancer screening provide a small reduction in a patient's uncertainty about which course of action to take and an increase in knowledge but have no impact on whether physicians discuss screening with men or whether men undergo screening, results of a systematic review and meta-analysis suggest.

Digital breast tomosynthesis now favored by more than 40% of hospital referral regions

NEW YORK (Reuters Health) - 27/6/2019

Digital breast tomosynthesis (DBT) is now the predominant mode of breast cancer screening in 41.8% of hospital referral regions, according to an analysis of Blue Cross Blue Shield claims.

Study shows major real-world impact of cervical cancer vaccines

LONDON (Reuters) - 27/6/2019

Vaccination against the virus that causes almost all cervical cancer is having a major impact on stopping infections and should significantly reduce cases of the disease within a decade, researchers said June 26 in The Lancet.

Targeted therapies linked to survival benefits for older patients with advanced renal cancer

NEW YORK (Reuters Health) - 21/6/2019

Targeted therapies were associated with "modest survival advantages" in elderly Medicare patients with metastatic renal cell carcinoma (mRCC) in a retrospective study.

Niraparib-pembrolizumab combo may have benefit in ovarian, breast cancers

NEW YORK (Reuters Health) - 20/6/2019

Niraparib in combination with pembrolizumab may show promise in women with recurrent platinum-resistant ovarian carcinoma (PROC) and in those with advanced or metastatic triple-negative breast cancer (TNBC), according to results from two industry-sponsored phase 2 trials.

Radical cystectomy cheaper than trimodal therapy in some bladder cancers

NEW YORK (Reuters Health) - 14/6/2019

In patients with localized muscle-invasive bladder cancer, radical cystectomy appears to have better outcome and may be much less costly than combining radiation, chemotherapy and endoscopic treatments, according to a retrospective study of Medicare data.

Adding radiation to chemo not better for locally-advanced endometrial cancer

(Reuters Health) - 12/6/2019

Supplementing chemotherapy with radiation failed to improve relapse-free survival in patients with stage III or IVA endometrial carcinoma, according to a comparison of the two therapies in 707 volunteers.

Checkpoint inhibitors may be retried after immune adverse event, with close monitoring

NEW YORK (Reuters Health) - 12/6/2019

After an immune-related adverse event, the risk-reward ratio for an anti-PD-1 (anti-programmed death-1) or anti-PD-L1 (anti-programmed death ligand-1) rechallenge seems to be acceptable if patients are closely monitored, researchers say.

Novel neoadjuvant approach may boost surgical success in pancreatic cancer

NEW YORK (Reuters Health) - 7/6/2019

In the majority of studied patients with locally advanced pancreatic cancer, total neoadjuvant treatment with fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFIRINOX) along with losartan and chemoradiation allowed complete tumor removal, according to a single-arm phase 2 trial.

Cardioprotective drugs can help avoid chemo disruption in some breast cancer patients

NEW YORK (Reuters Health) - 5/6/2019

ACE inhibitors or beta blockers can preserve cardiac function and avoid chemotherapy disruption in HER2-positive breast cancer patients treated with anthracyclines followed by trastuzumab, researchers say.

Venetoclax combination better than chlorambucil in CLL patients with coexisting conditions

(Reuters Health) - 4/6/2019

Among patients with chronic lymphocytic leukemia (CLL) and coexisting conditions such as heart, lung or digestive disease, adding venetoclax to obinutuzumab therapy produces longer progression-free survival than adding chlorambucil, newly-published results of the CLL14 trial have concluded.

Five-year study showed benefits of dabrafenib/trametinib therapy for metastatic melanoma

(Reuters Health) - 4/6/2019

Researchers combining the results of two large studies of volunteers with unresectable or metastatic melanoma have concluded that first-line therapy with dabrafenib combined with trametinib produces a 5-year benefit in about a third of patients with a BRAF V600E or V600K mutation.

Adding daratumumab cuts progression/death rate in newly-diagnosed multiple myeloma

(Reuters Health) - 31/5/2019

More than two years after treatment, patients with newly-diagnosed multiple myeloma fare better with daratumumab added to the standard therapy of lenalidomide plus dexamethasone instead of standard therapy alone, according to published results from the MAIA study of 737 volunteers.

Dual-drug induction therapy hikes survival in nasopharyngeal carcinoma

(Reuters Health) - 31/5/2019

In patients with locoregionally advanced nasopharyngeal carcinoma, adding gemcitabine and cisplatin induction to conventional treatment with platinum-based chemoradiotherapy increased the 3-year recurrence-free survival rate by 8.8 percentage points, according to results presented Friday at the American Society of Clinical Oncology's annual meeting in Chicago and online by the New England Journal of Medicine.

Apalutamide boosts progression-free survival by 52% in some prostate cancer patients

(Reuters Health) - 31/5/2019

In men with metastatic, castration-sensitive prostate cancer, adding apalutamide to conventional androgen-deprivation therapy (ADT) produced a 52% increase in the rate of radiographic progression-free survival, in a first interim analysis of the international TITAN study.

Drug combination may be effective against chronic lymphocytic leukemia

NEW YORK (Reuters Health) - 29/5/2019

Combining ibrutinib and venetoclax appears to produce complete remission or complete remission with incomplete normal-blood-count recovery in 88% of patients with chronic lymphocytic leukemia at one year, according to a new phase 2 study.

Guidelines not being followed for lymph node dissection in renal cancer

NEW YORK (Reuters Health) - 27/5/2019

Open radical nephrectomy for renal cell carcinoma (RCC) is associated with higher quality of lymph node dissection (LND), researchers report - but appropriate use of this approach is inconsistent.

Colorectal cancer rates rising in younger adults

NEW YORK (Reuters Health) - 24/5/2019

The incidence of colorectal cancer (CRC) in adults under age 50 years appears to be rising in both Europe and the United States, according to two new reports.

Novartis' breast cancer treatment wins FDA approval

(Reuters) - 24/5/2019

The U.S. Food and Drug Administration (FDA) said on Friday that it had approved Novartis AG's treatment in combination with a hormone therapy for postmenopausal women, as well as for men, with a form of advanced breast cancer.

Smoldering multiple myeloma less apt to progress with lenalidomide

NEW YORK (Reuters Health) - 23/5/2019

Lenalidomide cuts the risk that smoldering multiple myeloma, a precancerous condition, will progress to overt multiple myeloma in patients at moderate or high risk for progression, although side effects may be a limiting factor, according to results of a randomized controlled trial.

Dual-stain triage improves cervical cancer screening

NEW YORK (Reuters Health) - 16/5/2019

P16/Ki-67 dual-stain triage of women who test positive for human papillomavirus (HPV) in cervical cancer screening reduces referral to colposcopy without impairing detection of precancerous lesions, researchers report.

FDA okays Venclexta plus Gazyva for previously untreated chronic lymphocytic leukaemia

ZURICH (Reuters) - 16/5/2019

Roche said on Thursday that the U.S. Food and Drug Administration had approved Venclexta (venetoclax) in combination with Gazyva (obinutuzumab) for the treatment of people with previously untreated chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL).

Only 13% of patients eligible for checkpoint inhibitors respond to them

NEW YORK (Reuters Health) - 13/5/2019

About 44% of cancer patients may be eligible for an FDA-approved checkpoint inhibitor drug, yet approximately 13% will respond to them, researchers say.

Nipple-sparing mastectomy safe for more women with breast cancer

NEW YORK (Reuters Health) - 9/5/2019

More women with breast cancer can benefit from less-invasive nipple-sparing mastectomy, according to an analysis of data from the Mayo Clinic presented at the American Society of Breast Surgeons (ASBrS) annual meeting.

Numerous new anticancer drugs not proven superior to standard of care

NEW YORK (Reuters Health) - 9/5/2019

Seventeen percent of randomized controlled trials that led to new anticancer drug approvals in the U.S. had suboptimal control arms and did not prove superiority to standard-of-care treatments, a quality-improvement study shows.

Bioimpedance spectroscopy helps prevent breast cancer-related lymphedema progression

NEW YORK (Reuters Health) - 8/5/2019

For triggering compression therapy to prevent progression of breast cancer-related lymphedema, bioimpedance spectroscopy (BIS) appears to be more effective than standard tape measure (TM) assessment of arm circumference, according to interim results of the PREVENT trial reported May 2 at the American Society of Breast Surgeons annual meeting.

Molecular profiling identifies potential treatment targets in many hard-to-treat pediatric cancers

NEW YORK (Reuters Health) - 7/5/2019

Molecular profiling enables the identification of potentially treatable alterations in many hard-to-treat childhood and adolescent cancers, according to results from the TRICEPS study.

Low-dose tamoxifen prevents recurrence of in situ breast cancer

NEW YORK (Reuters Health) - 3/5/2019

Tamoxifen at a low dose helps reduce local and contralateral recurrence of breast intraepithelial neoplasia, according to a new randomized controlled trial.

HER2 testing inaccessible for many women with breast cancer

NEW YORK (Reuters Health) - 2/5/2019

A survey of HER2 testing of breast cancer in 45 countries highlights major issues around access and affordability in low- and middle-income countries (LMIC), with some problems extending even to upper-middle-income countries (UMIC).

High-dose, single-fraction SBRT likely effective for non-spine bone metastases

NEW YORK (Reuters Health) - 2/5/2019

Single-fraction stereotactic body radiotherapy (SBRT) seems to be an effective option for patients with painful non-spine bone metastases and achieved higher pain response rates than standard multifraction radiotherapy (MFRT) in a phase 2 noninferiority study.

Adverse events common with PD-1 and PD-L1 inhibitors

NEW YORK (Reuters Health) - 1/5/2019

Most cancer patients treated with programmed cell death (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors experience at least one treatment-related adverse event, according to a new systematic review and meta-analysis.

Bb2121 CAR-T multiple myeloma treatment effective, but benefits may wane

NEW YORK (Reuters Health) - 1/5/2019

Doctors testing a chimeric antigen receptor T-cell (CAR-T) therapy against relapsed or refractory multiple myeloma say results from 33 patients show a complete response rate of 45%, although 40% of those patients with a complete response ultimately relapsed.

Sipuleucel-T could be more widely used for advanced prostate cancer

NEW YORK (Reuters Health) - 25/4/2019

More men with advanced prostate cancer could benefit from immunotherapy with sipuleucel-T, according to researchers who found use of the drug was influenced by income and other factors.

Basal cell carcinoma subtype reporting varies by practice, may put patients at risk

NEW YORK (Reuters Health) - 25/4/2019

Underreporting of basal cell carcinoma (BCC) subtypes occurs in academic, teaching and nonteaching institutions and may place patients at risk for inadequate or inappropriate therapy, researchers say.

Adverse skin effects tied to anti-PD1 response in melanoma

NEW YORK (Reuters Health) - 24/4/2019

Cutaneous toxic effects (CT) following treatment with anti-programmed-cell-death 1 (anti-PD-1) inhibitors may be encouraging news in patients with advanced melanoma, a retrospective review suggests.

Pesticide exposure linked to worse outcomes in diffuse large B-cell lymphoma

NEW YORK (Reuters Health) - 23/4/2019

Diffuse large B-cell lymphoma (DLBCL) patients exposed to pesticides on the job have worse overall survival (OS) and event-free survival (EFS) and are less likely to respond to treatment, according to new findings.

MRI identifies rectal cancer patients suitable for primary surgery

NEW YORK (Reuters Health) - 23/4/2019

MRI criteria can be used to identify "good prognosis" rectal-cancer patients for primary surgery (without chemoradiotherapy first), according to results from the QuickSilver clinical trial.

Many young cancer patients regret initial treatment decisions

(Reuters Health) - 23/4/2019

Most teens and young adults with cancer want a voice in how their tumors are treated, but almost one in four express regret about the initial treatment decisions made, a small study suggests.

Promising results in mice prompt human trial of novel lymphoma vaccine

NEW YORK (Reuters Health) - 23/4/2019

An in situ vaccine (ISV) combined with immune stimulants and radiotherapy showed efficacy in mice, prompting a phase 1 trial of patients with advanced indolent non-Hodgkin's lymphoma (INHL), researchers say.

Promising strategy identifies triple-negative breast cancers that might respond to tamoxifen

NEW YORK (Reuters Health) - 23/4/2019

Triple-negative breast cancer (TNBC) tumors with estrogen receptor-beta and a mutated p53 tumor suppressor might be responsive to tamoxifen, a series of preclinical studies suggests.

Lower risk of new primary cancer after carbon-ion radiotherapy of localized prostate cancer

NEW YORK (Reuters Health) - 12/4/2019

The risk of subsequent primary cancer is lower after carbon-ion radiotherapy than after photon radiotherapy for localized prostate cancer, researchers from Japan report.

Genetic testing under-utilized in ovarian cancer

NEW YORK (Reuters Health) - 12/4/2019

Only a minority of women with ovarian or breast cancer undergo recommended genetic testing, a new study suggests.

Surgery after systemic therapy tied to improved outcome of HER2+ advanced breast cancer

NEW YORK (Reuters Health) - 5/4/2019

Surgery is associated with higher survival rates in women with HER2-positive stage-4 breast cancer treated with systemic therapy, a retrospective study shows.

Lenalidomide plus rituximab ups response in relapsed indolent lymphoma

NEW YORK (Reuters Health) - 3/4/2019

In patients with relapsed or refractory indolent non-Hodgkin lymphoma, adding lenalidomide to rituximab improves response, according to a placebo-controlled trial.

Umbralisib shows promise in relapsed/refractory marginal zone lymphoma

NEW YORK (Reuters Health) - 3/4/2019

Umbralisib, an investigational oral inhibitor of PI3K-delta, has significant activity against relapsed/refractory marginal-zone lymphoma (MZL) and manageable side effects, according to early results from an ongoing phase 2b trial.

Gilteritinib improves survival in relapsed/refractory acute myeloid leukemia

NEW YORK (Reuters Health) - 2/4/2019

Treatment with the FLT3 inhibitor gilteritinib (Xospata) improves survival for patients with relapsed or refractory acute myeloid leukemia (AML) harboring an FLT3 mutation compared with standard salvage chemotherapy, according to final results of the phase 3 ADMIRAL clinical trial.

Aspirin use tied to reduced liver-cancer risk in chronic hepatitis B

NEW YORK (Reuters Health) - 28/3/2019

Daily aspirin therapy is associated with a lower risk of hepatocellular carcinoma (HCC) in hepatitis B patients, new findings show.

Fulvestrant-anastrozole combo improves survival in metastatic breast cancer

(Reuters Health) - 27/3/2019

More than six years after a study showed that women with hormone-receptor-positive metastatic breast cancer benefit from a combination of anastrozole and fulvestrant, extended results show the trend has become even more pronounced, but mostly for women not previously exposed to tamoxifen.

Fewer benign biopsies with digital breast tomosynthesis

NEW YORK (Reuters Health) - 26/3/2019

Digital breast tomosynthesis (DBT) substantially reduces the rate of benign biopsies without hampering cancer detection, according to results from the U.K. National Health Service Breast Screening Program.

Screening ultrasonography does not improve breast-cancer detection

NEW YORK (Reuters Health) - 21/3/2019

Rates of breast-cancer detection are similar after screening mammography with or without screening ultrasonography, according to an observational study.

Liquid biopsy spots early liver cancer in patients with HBV infection

NEW YORK (Reuters Health) - 20/3/2019

In high-risk patients with asymptomatic hepatitis B virus (HBV) infection, a liquid biopsy shows promise in detecting early-stage hepatocellular carcinoma (HCC), according to Chinese and U.S. researchers.

Brain surgery for metastasis tied to distinctive tumor spread

NEW YORK (Reuters Health) - 19/3/2019

In the absence of whole-brain radiation, neurosurgical resection in patients with brain metastases may boost pachymeningeal seeding, a new study hints.

Better lymphoma outcomes with bendamustine-rituximab combination

NEW YORK (Reuters Health) - 15/3/2019

The combination of bendamustine and rituximab provides better progression-free survival (PFS), event-free survival, and duration of response in patients with indolent non-Hodgkin lymphoma and mantle-cell lymphoma, compared with other regimens, according to five-year results from the BRIGHT follow-up study.

Breast cancer risk tied to DDT varies by exposure timing

(Reuters Health) - 14/3/2019

The once-common pesticide DDT has long been linked to an increased risk of breast cancer. Now, research suggests that women's age at first exposure to DDT may influence when in life the risk for breast malignancies is greatest.

Survival low in some after recurrence of cutaneous squamous-cell carcinoma

NEW YORK (Reuters Health) - 12/3/2019

Patients with cutaneous squamous-cell cancer of the head and neck who have disease recurrence after definitive treatment with surgery and postoperative radiotherapy have poor survival, according to a retrospective study.

Consensus guidelines target maintenance therapies for lymphomas after autologous transplant

NEW YORK (Reuters Health) - 7/3/2019

Maintenance therapy guidelines for lymphoma patients who have undergone autologous hematopoietic cell transplantation (HCT) were recently released by an expert panel from the American Society for Blood and Marrow Transplantation, Center for International Blood and Marrow Transplant Research, and European Society for Blood and Marrow Transplantation.

Heart disease boosts risk for early death with abiraterone therapy for prostate cancer

NEW YORK (Reuters Health) - 6/3/2019

Men with advanced prostate cancer and cardiovascular disease (CVD) are at increased risk of dying during the first six months of treatment with abiraterone acetate (Zytiga) compared with their peers without pre-existing CVD, according to a retrospective study.

Liquid biopsy on par with tissue testing in advanced lung cancer

NEW YORK (Reuters Health) - 5/3/2019

In patients with newly diagnosed metastatic non-small-cell lung cancer (NSCLC), the Guardant360 liquid biopsy detects genomic biomarkers as well as standard-of-care tissue genotyping tests but with a faster turn-around time, new research suggests.

Study of AYA-cancer survivors can guide surveillance for new primary neoplasms

NEW YORK (Reuters Health) - 28/2/2019

A new study breaks down the excess risk of new primary malignancies in survivors of adolescent and young adult (AYA) cancers by the type of the first cancer, helping to inform surveillance efforts.

Heart-failure risk increased after adjuvant trastuzumab for breast cancer

NEW YORK (Reuters Health) - 28/2/2019

The long-term risk of heart failure nearly doubles after adjuvant chemotherapy with trastuzumab in breast cancer patients, according to a retrospective cohort study.

New tool predicts post-surgery problems in head and neck cancer

NEW YORK (Reuters Health) - 28/2/2019

A new preoperative risk index can help predict short-term adverse events (AEs) following surgery for head and neck cancer, according to Canadian researchers.

Advanced ovarian cancer survival not better with pelvic, paraaortic lymphadenectomy

(Reuters Health) - 27/2/2019

Women with advanced ovarian cancer and normal lymph nodes after complete resection experience no survival benefit from systematic pelvic and paraaortic lymphadenectomy, a randomized study of 647 volunteers has concluded.

Hypofractionated radiotherapy appropriate for low-risk prostate cancer

NEW YORK (Reuters Health) - 22/2/2019

Hypofractionated radiotherapy (HRT) should be a new practice standard for men with low-risk prostate cancer, based on a secondary analysis of a phase III trial.

Stereotactic ablative radiotherapy tops for inoperable early non-small-cell lung cancer

NEW YORK (Reuters Health) - 21/2/2019

Compared with standard radiotherapy, stereotactic ablative body radiotherapy (SABR) provides better local control and improved survival in patients with inoperable peripherally located stage 1 non-small-cell lung cancer (NSCLC), according to results of the CHISEL study.

Risk profile predicts survival in transplant-ineligible multiple myeloma

NEW YORK (Reuters Health) - 21/2/2019

In patients with multiple myeloma who are ineligible for stem-cell transplantation, the UK Myeloma Research Alliance Risk Profile (MRP) predicts overall survival across treatments and genetic factors, researchers say.

Tisotumab vedotin shows some promise in early trial of solid tumors

NEW YORK (Reuters Health) - 19/2/2019

A new cancer drug has shown promise against multiple tumor types, in a first-in-human trial.

Neoadjuvant anti-PD-1 immunotherapy may improve glioblastoma outcomes

NEW YORK (Reuters Health) - 15/2/2019

Neoadjuvant immunotherapy with anti-PD-1 agents may improve outcomes in patients with resectable or recurrent glioblastoma, researchers report.

Expanding genetic testing for prostate cancer could improve patient management

NEW YORK (Reuters Health) - 15/2/2019

Expanding genetic testing beyond current guidelines could better stratify prostate cancer patients for the presence of pathogenic variants and improve their medical management, researchers say.

Novel radiation therapy promising for metastatic castration-resistant prostate cancer

NEW YORK (Reuters Health) - 14/2/2019

A novel, targeted radiation therapy called Lutetium-177 PSMA-617 (LuPSMA) has shown promising clinical activity in men with prostate-specific membrane antigen (PSMA)-positive metastatic, castration-resistant prostate cancer (mCRPC) that progressed despite multiple standard therapies.

Stereotactic body radiotherapy shows long-term safety in prostate cancer

NEW YORK (Reuters Health) - 14/2/2019

Stereotactic body radiotherapy (SBRT) appears to provide good long-term results and very few toxic effects in certain prostate cancers, according to data from thousands of patients.

Histological subtype best outcome predictor in orbital lymphoma

NEW YORK (Reuters Health) - 8/2/2019

How well orbital lymphoma (OL) patients do depends mainly on which of four subtypes they have, a new case series suggests.

Hyperthermic intraperitoneal chemo relatively safe for treating metastases

NEW YORK (Reuters Health) - 7/2/2019

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) appears to be at least as safe as other high-risk surgical oncology procedures, according to a retrospective study.

Hypothermic intraperitoneal chemo relatively safe for treating metastases

NEW YORK (Reuters Health) - 31/1/2019

Cytoreductive surgery with hypothermic intraperitoneal chemotherapy (CRS/HIPEC) appears to be at least as safe as other high-risk surgical oncology procedures, according to a retrospective study.

Focal cryotherapy shows encouraging prostate cancer control

NEW YORK (Reuters Health) - 31/1/2019

Focal cryotherapy for nonmetastatic clinically significant prostate cancer shows largely good outcomes at up to three years, according to UK researchers.

'Dense' breast rates steady with changing guidelines and technology

NEW YORK (Reuters Health) - 30/1/2019

The percentage of digital mammography screens assessed as dense has remained steady with changes in Breast Imaging Reporting and Data System (BI-RADS) guidelines and implementation of digital breast tomosynthesis, according to findings from the Breast Cancer Surveillance Consortium (BCSC).

Improved head and neck cancer survival with NSAIDs

NEW YORK (Reuters Health) - 29/1/2019

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with improved survival in patients with PIK3CA-altered head and neck cancer, researchers report.

Long-lasting menopause symptoms may be tied to slightly higher breast cancer risk

(Reuters Health) - 17/1/2019

Women who experience symptoms of menopause for many years may be slightly more likely to develop breast cancer than women who never had these symptoms, a U.S. study suggests.

Tumor markers limit imaging need in germ-cell tumor surveillance

NEW YORK (Reuters Health) - 16/1/2019

Tumor markers are a sensitive, radiation-sparing means of surveillance in children and adolescents with malignant germ-cell tumors, according to a retrospective review.

Task force adds aromatase inhibitors to advice on breast cancer chemoprevention in high-risk women

NEW YORK (Reuters Health) - 15/1/2019

In addition to tamoxifen and raloxifene, aromatase inhibitors (AIs) may now be considered for chemoprevention of breast cancer in women at high risk, the U.S. Preventive Services Task Force (USPSTF) said today in draft recommendations on the topic.

Life expectancy predicts benefit of immune-checkpoint inhibitors

NEW YORK (Reuters Health) - 15/1/2019

Late-life expectancy (LLE) is a better measure of survival benefit with immune-checkpoint inhibitors than is the American Society of Clinical Oncology Value Framework (ASCO-VF), according to a new report.

Respiratory medicine

A third of patients with severe asthma are taking risky doses of oral steroids

NEW YORK (Reuters Health) - 11/10/2019

About a third of patients with severe asthma in the Netherlands are taking harmful doses of oral steroids, and poor access to biologic drugs could be playing a part, according to new research.

Blood test helps identify pneumonia patients at risk for acute respiratory failure or sepsis

NEW YORK (Reuters Health) - 10/10/2019

A blood test can identify a subgroup of pneumonia patients at increased risk for developing acute respiratory failure or sepsis, according to new research.

Unexpectedly high malignancy rates in subsolid lung nodules

NEW YORK (Reuters Health) - 8/10/2019

The malignancy rates of Lung-RADS category-2 and category-3 subsolid lung nodules are much higher than reported, according to an analysis of nodules from the National Lung Screening Trial (NLST).

COPD intervention linked to more, not fewer, hospitalizations

NEW YORK (Reuters Health) - 8/10/2019

An intervention for patients with chronic obstructive pulmonary disease (COPD) that combines transitional care and long-term self-management support is associated with more hospitalizations and emergency department visits, compared with usual care, researchers report in JAMA.

In-home initiation of non-invasive ventilation for COPD patients safe, feasible

NEW YORK (Reuters Health) - 7/10/2019

For patients with chronic obstructive pulmonary disease (COPD) and stable hypercapnic respiratory failure, initiating chronic non-invasive ventilation (NIV) at home is as effective as doing so in a hospital, Dutch researchers have found.

Transbronchial lung cryobiopsy a valid diagnostic option in interstitial lung disease

NEW YORK (Reuters Health) - 4/10/2019

Transbronchial lung cryobiopsy (TBLC) and surgical lung biopsy (SLB) had a high level of agreement for diagnosing interstitial lung disease in the first comparative study.

New dual antimicrobial effective for nosocomial pneumonia

NEW YORK (Reuters Health) - 2/10/2019

The combined antibacterial ceftolozane-tazobactam, sold as Zerbaxa by Merck, is a safe and effective option for nosocomial pneumonia, according to results of the noninferiority trial that led to approval of the drug for this indication in the U.S. in June.

Clinical T category may suffice for lung cancer prognosis

NEW YORK (Reuters Health) - 2/10/2019

The clinical T category in the eighth edition of the tumor-node-metastasis (TNM) staging for lung cancer is a "powerful" prognostic factor, such that consolidation-to-tumor ratio (CTR) and tumor disappearance ratio (TDR) may no longer be needed, researchers say.

Single-inhaler triple therapy improves outcomes in uncontrolled asthma

NEW YORK (Reuters Health) - 2/10/2019

Patients with uncontrolled asthma have improved outcomes with use of a single inhaler containing a corticosteroid (ICS), a long-acting beta2 agonist (LABA) and a long-acting muscarinic antagonist (LAMA), according to results from the TRIMARAN and TRIGGER randomized clinical trials.

TP53, ATM comutation might help guide lung-cancer immunotherapy

NEW YORK (Reuters Health) - 1/10/2019

In patients with non-small-cell lung cancer (NSCLC), the presence of tumor protein p53 (TP53) and ataxia-telangiectasia mutated (ATM) comutation might indicate better response to immune-checkpoint inhibitors (ICIs), according to Chinese researchers.

Nintedanib slows lung deterioration in general fibrosing interstitial lung disease

NEW YORK (Reuters Health) - 30/9/2019

Nintedanib dramatically slows lung deterioration in patients with progressive fibrosing interstitial lung diseases, according to a new randomized study of the Boehringer Ingelheim drug.

Dupilumab offers relief for severe chronic rhinosinusitis with nasal polyps

NEW YORK (Reuters Health) - 27/9/2019

Dupilumab reduces polyp size and symptom severity in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP), according to results from two randomized clinical trials.

CT radiation doses for lung-cancer screening vary widely

NEW YORK (Reuters Health) - 25/9/2019

CT radiation doses used for lung-cancer screening vary widely within and between institutions, researchers report.

Anxiety, depression tied to more ER visits with childhood asthma

(Reuters Health) - 25/9/2019

For young people with asthma, mood disorders are linked with higher odds of visiting the emergency room, a new study suggests.

Can ultrasonography accurately diagnose ARDS?

NEW YORK (Reuters Health) - 23/9/2019

Ultrasonography (US) allows for bedside detection of acute respiratory disease syndrome (ARDS) without radiation and should be more widely used, researchers in Italy suggest.

Sleep-disordered breathing tied to multiple causes in young children

NEW YORK (Reuters Health) - 20/9/2019

Both early- and late-onset sleep-disordered breathing (SDB) are associated with various conditions that cause pharyngeal dysfunction in young children, a retrospective study reveals

E-sniffer predicts non-responders to lung cancer immunotherapy

(Reuters Health) - 19/9/2019

An electronic "nose" that detects chemicals in the breath of lung cancer patients may help distinguish between those who will and will not respond to immunotherapy, a new study suggests.

Adding metformin to advanced lung cancer therapy may boost survival

NEW YORK (Reuters Health) - 12/9/2019

Adding metformin to standard epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) therapy in patients with advanced lung cancer improved progression-free and overall survival in a phase 2 trial in Mexico.

Budesonide-formoterol inhaler p.r.o. reduces adult asthma exacerbations

NEW YORK (Reuters Health) - 11/9/2019

As-needed use of a budesonide-formoterol inhaler is more effective than maintenance budesonide plus terbutaline reliever therapy for reducing severe exacerbations in adults with mild to moderate asthma, according to results from the randomized PRACTICAL trial.

E-cigarette lung damage manifests as a range of lung problems

NEW YORK (Reuters Health) - 9/9/2019

Vaping-related lung damage can initially present as a variety of conditions such as acute eosinophilic pneumonia, lipoid pneumonia and organizing pneumonia, according to researchers.

Gaps in cancer patients' understanding of genomic testing

NEW YORK (Reuters Health) - 3/9/2019

Most cancer patients who participate in biomarker-driven clinical trials don't understand the genomic test results they get, according to a pilot study conducted under the Lung Cancer Master Protocol (Lung-MAP).

Nivolumab still has edge on chemo after 4 years in advanced NSCLC

NEW YORK (Reuters Health) - 2/9/2019

Patients with advanced non-small-cell lung cancer (NSCLC) who are treated with the anti-PD-1 antibody nivolumab continue to have better survival than those given docetaxel after four years, according to pooled data from four CheckMate trials.

Combination approach appears best in advanced lung cancer

NEW YORK (Reuters Health) - 30/8/2019

In patients with stage-IV non-small-cell lung cancer (NSLCC), systemic therapy by itself appears less effective in reducing mortality risk than when it's used with other treatment modalities, according to a retrospective study.

EGFR inhibitors prolong survival in resected non-small-cell lung cancer

NEW YORK (Reuters Health) - 29/8/2019

EGFR tyrosine kinase inhibitors (TKIs) added to chemotherapy prolong overall and disease-free survival (DFS) in patients with resected non-small cell lung cancer (NSCLC) bearing EGFR mutations, researchers in China report.

Illinois reports death from lung illness linked to vaping

(Reuters) - 23/8/2019

A person in Illinois who vaped has died after being hospitalized with severe respiratory illness, the state's health authorities said on Friday, amid reports that dozens of people had been sickened with lung problems linked to vaping.

Use of prophylactic cranial irradiation for extensive-stage small-cell lung cancer may be dropping

NEW YORK (Reuters Health) - 22/8/2019

Prophylactic cranial irradiation (PCI) for patients with extensive-stage small-cell lung cancer (ES-SCLC) appears to have become less common in the U.S., according to a new survey.

AstraZeneca Imfinzi combination fails advanced lung cancer study

(Reuters) - 21/8/2019

A combination of AstraZeneca's lung cancer drug Imfinzi and an experimental treatment failed to extend the lives of patients with advanced non-small cell lung cancer (NSCLC) and high levels of gene mutations, the drugmaker said on Wednesday.

Guideline helps spot pulmonary embolism in cancer patients

NEW YORK (Reuters Health) - 16/8/2019

Using the American College of Physicians (ACP) guideline to evaluate cancer patients presenting to the emergency department who may have pulmonary embolism (PE) can help curtail the need for procedures such as CT pulmonary angiography (CTPA), a retrospective study suggests.

Air pollution can damage even healthy lungs

Reuters Health - 14/8/2019

The more exposure people have to air pollution, especially ozone, the more lung damage they develop over time, a U.S. study suggests.

Telemedicine may boost unnecessary antibiotic prescribing in kids

NEW YORK (Reuters Health) - 1/8/2019

Antibiotics are often prescribed to children with respiratory tract infections (RTIs) during video-only direct-to-consumer (DTC) telemedicine visits, and parents are more satisfied with the video visit when it results in a prescription, a new study has found.

Lung-cancer-screening eligibility should be expanded

NEW YORK (Reuters Health) - 18/7/2019

U.S. Preventive Services Task Force (USPSTF) eligibility criteria for lung-cancer screening should be expanded to cover other risk groups, researchers say based on findings from an observational study.

Unclear which inhaled steroids least affect growth in asthmatic children

Source: Reuters - 16/7/2019

It's not clear which inhaled corticosteroids and delivery devices have the least adverse impact on growth in children with persistent asthma, a systematic review concludes.

Less snoring and fatigue in sleep apnea patients with nasal polyps

NEW YORK (Reuters Health) - 15/7/2019

A study of men with chronic rhinosinusitis with nasal polyps (CRSwNP) and obstructive sleep apnea (OSA) shows that symptoms may be less pronounced than in those with classic OSA, according to Brazilian researchers.

Smoking normalizes dynamic brain activity in schizophrenia

Source: Reuters - 15/7/2019

Nicotine restores dynamic intrinsic brain activity in the left dorsolateral prefrontal cortex (DLPFC) of people with schizophrenia, researchers from China have found.

Vaping may aid smoking cessation but also boost relapse risk

Source: Reuters - 15/7/2019

Adults who smoke cigarettes may have an easier time cutting back or quitting altogether if they start vaping, but a new French study also suggests that vaping may make ex-smokers more likely to relapse.

CRP testing lowers antibiotic use in COPD exacerbations

NEW YORK (Reuters Health) - 10/7/2019

Testing for C-reactive protein (CRP) can reduce unnecessary antibiotic use in patients experiencing an exacerbation of chronic obstructive pulmonary disease (COPD), according to the results of a randomized clinical trial.

Poorly-controlled asthma commonly affects pregnancy in U.S.

(Reuters Health) - 10/7/2019

Asthma is often not well controlled during pregnancy, especially among publicly-insured women, according to a U.S. study.

Rethink antibiotics before discharging pneumonia patients, researchers say

NEW YORK (Reuters Health) - 9/7/2019

Patients hospitalized with pneumonia who receive antibiotic treatment longer than recommended durations have increased odds of reporting antibiotic-associated adverse events after discharge, according to a retrospective study.

WHO keeps key lung cancer drugs off its essential medicines list

GENEVA/ZURICH (Reuters) - 9/7/2019

Immunotherapies that have emerged as a breakthrough in treating lung cancer have been rejected for inclusion on the World Health Organization's list of "essential medicines", which received a biennial update on Tuesday.

Antioxidants enhance lung cancer metastasis by stabilizing BACH1

NEW YORK (Reuters Health) - 8/7/2019

Antioxidants can contribute to lung cancer metastasis by stabilizing the transcription factor BACH1, researchers report.

High prevalence of PD-L1 expression in non-small-cell lung cancer

NEW YORK (Reuters Health) - 5/7/2019

The expression of programmed death ligand 1 (PD-L1) is common in locally advanced or metastatic non-small-cell lung cancer (NSCLC), according to a retrospective study across 18 countries.

San Francisco bans e-cigarette sales

(Reuters) - 26/6/2019

San Francisco will become the first major city in the United States to ban the sale of e-cigarettes as officials look to control the rapid uptick in teenage use of nicotine devices made by companies such as Juul Labs Inc.

EU court orders countries take hard line on air quality

BRUSSELS (Reuters) - 26/6/2019

The European Union's top court ruled on Wednesday that cities needed to act if pollution levels were exceeded in a single black spot rather than based on an average across a region, taking a hard line in a case brought by Brussels residents.

Study supports current airflow-obstruction threshold for COPD diagnosis

NEW YORK (Reuters Health) - 25/6/2019

A new study supports current guidelines stating that a diagnosis of chronic obstructive pulmonary disease (COPD) requires a ratio of the forced expiratory volume in the first second to the forced vital capacity (FEV1:FVC) of less than 0.70.

Lung cancer radiotherapy tied to higher cardiac mortality

NEW YORK (Reuters Health) - 18/6/2019

In patients with locally advanced non-small-cell lung cancer undergoing radiotherapy, cardiac radiation exposure is an independent predictor of adverse outcomes, according to a retrospective analysis.

More than a third of people in the Americas may suffer from obstructive sleep apnea

NEW YORK (Reuters Health) - 14/6/2019

Obstructive sleep apnea (OSA) may affect as many as 37% of adults in the Americas, according to a review of epidemiological studies presented June 9 at Sleep 2019, the annual meeting of the Associated Professional Sleep Societies in San Antonio, Texas.

Enanta's lung infection therapy succeeds in mid-stage trial

(Reuters) - 14/6/2019

Enanta Pharmaceuticals Inc said on Friday its treatment for a highly contagious respiratory infection met the main goal of reducing virus levels in the body in a mid-stage study.

Early discharge, home treatment with rivaroxaban effective in low-risk pulmonary embolism

NEW YORK (Reuters Health) - 5/6/2019

Carefully selected patients with acute low-risk pulmonary embolism (PE) may be discharged early and treated at home safely and effectively with rivaroxaban, researchers say.

Broadening eligibility for lung cancer trials could have huge impact

NEW YORK (Reuters Health) - 5/6/2019

Adopting expanded inclusion criteria for clinical trials would nearly double the percentage of patients with advanced non-small-cell lung cancer (NSCLC) who are eligible to enroll, according to new research.

Stocking albuterol inhalers at schools could improve emergency asthma management

NEW YORK (Reuters Health) - 4/6/2019

Pediatricians should advocate for stocking albuterol inhalers at schools as a means of improving the management of asthma emergencies.

Atezolizumab added to chemo ups survival in lung cancer

NEW YORK (Reuters Health) - 31/5/2019

As first-line treatment for metastatic non-squamous non-small-cell lung cancer (NSCLC), the anti-PD-L1 agent atezolizumab (Tecentriq, Genentech) in combination with chemotherapy boosts survival compared with chemotherapy alone, according to a company-funded study.

Longer lung-cancer-screening intervals may sometimes be OK

NEW YORK (Reuters Health) - 27/5/2019

Lung-cancer-screening intervals longer than the current annual screening might be reasonable for some patients with neither emphysema nor consolidation on their lung CT, according to findings from the National Lung Screening Trial (NLST).

Benralizumab does not reduce COPD exacerbations

NEW YORK (Reuters Health) - 24/5/2019

Benralizumab, which depletes eosinophils, does not reduce exacerbations in patients with moderate to severe chronic obstructive pulmonary disease (COPD), according to results from two phase 3 trials.

Nintedanib slows progression of systemic sclerosis-associated interstitial lung disease

NEW YORK (Reuters Health) - 24/5/2019

Nintedanib slows the decline of forced vital capacity (FVC) in patients with systemic sclerosis-associated interstitial lung disease (ILD), according to findings from the SENSCIS trial.

Self-management app may improve outcomes in kids with persistent asthma

NEW YORK (Reuters Health) - 16/5/2019

AsthmaTracker, an electronic self-monitoring app for children with asthma, appears to increase participation in self-monitoring and improves asthma outcomes, according to a prospective study.

E-cigarettes and tobacco cigarettes induce similar acute respiratory response

NEW YORK (Reuters Health) - 15/5/2019

Short-term respiratory responses to use of e-cigarettes and tobacco cigarettes are similar, researchers say.

Vein-first ligation in lung-cancer surgery may increase survival

NEW YORK (Reuters Health) - 14/5/2019

Ligating effluent veins rather than arteries first during thoracoscopic lobectomy for non-small-cell lung cancer may reduce tumor-cell dissemination and hence increase survival, according to Chinese researchers.

New technique for minimally invasive lung cancer surgery promising

NEW YORK (Reuters Health) - 10/5/2019

A device that uses ultrasonic energy to seal pulmonary blood vessels during minimally invasive lung cancer surgery is a promising alternative to staplers and clips, researchers reported in a late-breaking clinical trial session May 4 at the American Association for Thoracic Surgery (AATS) annual meeting in Toronto.

Aclidinium bromide does not worsen cardiovascular outcomes in COPD

NEW YORK (Reuters Health) - 8/5/2019

The long-acting muscarinic antagonist (LAMA) aclidinium bromide reduces exacerbations of chronic obstructive pulmonary disease (COPD) without worsening cardiovascular outcomes in high-risk patients, according to results from the ASCENT-COPD randomized clinical trial.

Deep-learning model may help predict NSCLC outcomes, survival

NEW YORK (Reuters Health) - 30/4/2019

A deep-learning model that uses serial imaging scans of tumors from patients with non-small-cell lung cancer (NSCLC) may predict treatment response and survival better than standard clinical parameters alone, researchers say.

Higher radiation doses tied to increased longevity in node-negative lung cancer

NEW YORK (Reuters Health) - 30/4/2019

Patients with node-negative stage-II non-small cell lung cancer (NSCLC) who receive higher radiation doses survive longer, researchers have found.

Lung-cancer survival worse in patients with pulmonary fibrosis

NEW YORK (Reuters Health) - 25/4/2019

Non-small cell lung cancer (NSCLC) presents differently in patients with idiopathic pulmonary fibrosis (IPF), who also have higher overall and lung-cancer mortality, according to a new study.

Molecular classifier helps spot idiopathic pulmonary fibrosis

NEW YORK (Reuters Health) - 10/4/2019

A molecular classifier based on RNA-sequencing data from transbronchial lung biopsies can recognize an expression signature associated with usual interstitial pneumonia (UIP), the defining pathology of idiopathic pulmonary fibrosis (IPF).

Pembrolizumab may help some with advanced non-small-cell lung cancer

NEW YORK (Reuters Health) - 2/4/2019

Pembrolizumab (Keytruda, Merck) may have ongoing benefits for people with advanced non-small-cell lung cancer expressing programmed death ligand 1 (PD-L1), extended follow-up of an open-label study shows.

Next-generation sequencing assay detects genetic variants driving cancer, resistance in NSCLC

NEW YORK (Reuters Health) - 2/4/2019

A novel liquid biopsy based on ultra-deep next-generation sequencing (NGS) of plasma cell-free DNA (cfDNA) can detect oncogenic drivers and resistance mutations in non-small-cell lung cancer (NSCLC), even when tissue biopsy fails to do so, researchers say.

Algorithm automatically detects major thoracic diseases on chest x-rays

NEW YORK (Reuters Health) - 29/3/2019

A new deep-learning-based automated-detection (DLAD) algorithm accurately classifies major thoracic diseases on chest x-rays, researchers from South Korea report.

Cranial irradiation doesn't boost survival in locally advanced lung cancer

NEW YORK (Reuters Health) - 26/3/2019

Prophylactic cranial irradiation (PCI) doesn't appear to increase overall survival (OS) in patients with locally advanced non-small-cell lung cancer (LA-NSCLC), long-term data from a phase 3 trial suggest.

Amphotericin B makes path for lung defense in cystic fibrosis

NEW YORK (Reuters Health) - 22/3/2019

Amphotericin B treatment may be able to restore the infection-fighting properties of the lungs in cystic fibrosis by standing in for a missing or deficient protein channel, studies in pigs and in human lung tissue suggest.

Expansion sphincter pharyngoplasty may help some with sleep apnea

NEW YORK (Reuters Health) - 14/3/2019

Expansion sphincter pharyngoplasty could be a useful surgical option in certain patients with obstructive sleep apnea (OSA), a retrospective study from South Korea hints.

Lung-cancer screens effective in asbestos-exposed smokers

NEW YORK (Reuters Health) - 14/3/2019

Low-dose computed tomography (LDCT) screening can detect early lung cancers in smokers with a history of occupational asbestos exposure, new research shows.

Poor asthma control linked with kids' school struggles

(Reuters Health) - 11/3/2019

Kids with asthma may struggle more in school when their symptoms aren't well-controlled, and minority students with this breathing disorder are more likely to fall behind than their white counterparts, a U.S. study suggests.

It's never too late to quit smoking before lung surgery

(Reuters Health) - 16/1/2019

Smokers preparing for lung cancer surgery should quit smoking before the operation, and the sooner the better, a new study shows.

Lung cancer screening complications may be higher than expected

(Reuters Health) - 14/1/2019

Invasive follow-up tests to examine abnormalities found with lung cancer screening may lead to more complications and extra healthcare costs than previously thought, a U.S. study suggests.

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